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Review
. 2020 May;18(6):1268-1279.
doi: 10.1016/j.cgh.2019.10.035. Epub 2019 Oct 30.

Positioning Therapies in the Management of Crohn's Disease

Nghia H Nguyen  1 , Siddharth Singh  2 , William J Sandborn  3
Affiliations
Review

Positioning Therapies in the Management of Crohn's Disease

Nghia H Nguyen et al. Clin Gastroenterol Hepatol. 2020 May.

Abstract

In the past decade, several new therapies with different mechanisms of action have been approved for the management of moderate to severe Crohn's disease. However, there is limited guidance on optimal positioning of agents as first- or second-line therapies because of the absence of head-to-head trials. Furthermore, given the lack of comparative studies, treatment guidelines have provided limited insight. In this review, we discuss data on key treatment attributes, comparative efficacy and safety, factors predictive of response to each agent, and propose an algorithm for positioning therapies for the management of patients with low-risk and high-risk Crohn's disease.

Keywords: Biologics; Crohn's; IBD; Therapies; Treatment.

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Conflict of interest statement

Conflicts of Interest:

Figures

Figure 1.
Figure 1.
Proposed algorithm for positioning therapies for patients with low-risk Crohn’s disease
Figure 2.
Figure 2.
Proposed algorithm for positioning therapies for patients with high-risk Crohn’s disease
See this image and copyright information in PMC

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