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Review
. 2019 Nov;20(11):e622-e635.
doi: 10.1542/neo.20-11-e622.

Update on Erythropoiesis-Stimulating Agents Administered to Neonates for Neuroprotection

Jessie R Maxwell  1 , Robin K Ohls  2
Affiliations
Review

Update on Erythropoiesis-Stimulating Agents Administered to Neonates for Neuroprotection

Jessie R Maxwell et al. Neoreviews. 2019 Nov.

Abstract

Erythropoiesis-stimulating agents (ESAs) such as erythropoietin and darbepoetin have been studied as red blood cell growth factors in preterm and term infants for more than 30 years. Recently, studies have focused on the potential neuroprotective effects of ESAs. In this review, we summarize preclinical animal models and recent clinical trials that provide evidence for ESAs as potential treatments to improve neurodevelopmental outcomes in preterm and term infants.

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