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Review
. 2020 Jan:129:110750.
doi: 10.1016/j.exger.2019.110750. Epub 2019 Oct 31.

Biomarkers in the path from cellular senescence to frailty

Marta Zampino  1 , Luigi Ferrucci  2 , Richard D Semba  3
Affiliations
Review

Biomarkers in the path from cellular senescence to frailty

Marta Zampino et al. Exp Gerontol. 2020 Jan.
No abstract available

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Conflict of interest statement

Declaration of interest: none.

Figures

Figure 1.
Figure 1.
Hypothesized mechanism by which senescent cells contribute to age-related conditions. Senescent cells produce the Senescence-Associated Secretory Phenotype (SASP), rich in inflammatory molecules, which in turn induce aging of the tissues and age-related diseases. TNF-α, tumor necrosis factor-α; MMP, matrix metalloproteinases; IL-1, interleukin-1; ICAM, intracellular adhesion molecules; IL-7, interleukin-7; IL-6, interleukin-6; IL-8, interleukin-8; VEGF, vascular endothelial growth factor; CCL-2, chemokine (C-C motif) ligand 2; EGF, endothelial growth factor.
See this image and copyright information in PMC

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