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Meta-Analysis
. 2020 Jan;124(1):e4-e7.
doi: 10.1016/j.bja.2019.09.036. Epub 2019 Nov 1.

Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis

Mary Cooter  1 , Katherine Ni  2 , Jake Thomas  1 , Dhanesh K Gupta  1 , Thomas J Hopkins  1 , Timothy E Miller  1 , Michael L James  1 , Miklos D Kertai  3 , Miles Berger  4
Affiliations
Meta-Analysis

Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis

Mary Cooter et al. Br J Anaesth. 2020 Jan.
No abstract available

Keywords: age; inhaled anaesthetic; minimum alveolar concentration; potency.

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Figures

Fig 1
Fig 1
Meta-regression of the effect of age on minimum alveolar concentration (MAC) from all published MAC data in individuals of various ages from Table 1, including all those reviewed by Mapleson and all additional MAC studies since 1996.
See this image and copyright information in PMC

References

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    1. Eger E.I., 2nd Age, minimum alveolar anesthetic concentration, and minimum alveolar anesthetic concentration-awake. Anesth Analg. 2001;93:947–953. - PubMed
    1. Ni K., Cooter M., Gupta D.K. Paradox of age: older patients receive higher age adjusted MAC values, yet display higher average BIS values. Br J Anaesth. 2019;12:288–297. - PMC - PubMed
    1. Van Cleve W.C., Nair B.G., Rooke G.A. Associations between age and dosing of volatile anesthetics in 2 academic hospitals. Anesth Analg. 2015;121:645–651. - PubMed
    1. Wadhwa A., Durrani J., Sengupta P., Doufas A., Sessler D.I. Women have the same desflurane minimum alveolar concentration as men: a prospective study. Anesthesiology. 2003;99:1062–1065. - PMC - PubMed

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