Asthenozoospermia: Cellular and molecular contributing factors and treatment strategies

doi:10.1111/and.13463

Review

. 2020 Mar;52(2):e13463.

doi: 10.1111/and.13463. Epub 2019 Nov 3.

Asthenozoospermia: Cellular and molecular contributing factors and treatment strategies

Seyedeh Zahra Shahrokhi¹, Peyman Salehi², Atieh Alyasin³, Sana Taghiyar⁴, Mohammad Reza Deemeh^{4

5}

Affiliations

¹ Department of Laboratory Medicine, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Infertility Center, Shahid Beheshti Hospital, Isfahan, Iran.
³ Department of Biology, Arak University, Arak, Iran.
⁴ Andrology Department, Nobel Laboratory, Isfahan, Iran.
⁵ Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

PMID: 31680293
DOI: 10.1111/and.13463

Review

Asthenozoospermia: Cellular and molecular contributing factors and treatment strategies

Seyedeh Zahra Shahrokhi et al. Andrologia. 2020 Mar.

. 2020 Mar;52(2):e13463.

doi: 10.1111/and.13463. Epub 2019 Nov 3.

Authors

Seyedeh Zahra Shahrokhi¹, Peyman Salehi², Atieh Alyasin³, Sana Taghiyar⁴, Mohammad Reza Deemeh^{4

5}

Affiliations

¹ Department of Laboratory Medicine, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Infertility Center, Shahid Beheshti Hospital, Isfahan, Iran.
³ Department of Biology, Arak University, Arak, Iran.
⁴ Andrology Department, Nobel Laboratory, Isfahan, Iran.
⁵ Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

PMID: 31680293
DOI: 10.1111/and.13463

Abstract

Semen sample with poor sperm motility, which called asthenozoospermia, is considered as one of the main factors contributing to male infertility. Recognition of the cellular and molecular pathways contributing to sperm motility reduction may lead to applying novel treatment strategies for overcoming low sperm motility in asthenozoospermia individuals. In this review, we intend to discuss the main causes of sperm motility reduction in asthenozoospermia and some treatment strategies used to overcome low sperm motility.

Keywords: apoptosis; reactive oxygen species; spermiogenesis.

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References

REFERENCES

1. Afzelius, B. A. (2004). Cilia-related diseases. The Journal of Pathology, 204(4), 470-477. https://doi.org/10.1002/path.1652
1. Aitken, R. J. (2017). Reactive oxygen species as mediators of sperm capacitation and pathological damage. Molecular Reproduction and Development, 84(10), 1039-1052. https://doi.org/10.1002/mrd.22871
1. Aitken, R. J., & Baker, M. A. (2013). Causes and consequences of apoptosis in spermatozoa; Contributions to infertility and impacts on development. International Journal of Developmental Biology, 57(2-4), 265-272. https://doi.org/10.1387/ijdb.130146ja
1. Aitken, R. J., Gibb, Z., Baker, M. A., Drevet, J., & Gharagozloo, P. (2016). Causes and consequences of oxidative stress in spermatozoa. Reproduction, Fertility, and Development, 28(1-2), 1-10. https://doi.org/10.1071/rd15325
1. Aitken, R. J., Ross, A., & Lees, M. M. (1983). Analysis of sperm function in Kartagener's syndrome. Fertility and Sterility, 40(5), 696-698. https://doi.org/10.1016/S0015-0282(16)47434-0

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[1] Afzelius, B. A. (2004). Cilia-related diseases. The Journal of Pathology, 204(4), 470-477. https://doi.org/10.1002/path.1652

[2] Afzelius, B. A. (2004). Cilia-related diseases. The Journal of Pathology, 204(4), 470-477. https://doi.org/10.1002/path.1652

[3] Aitken, R. J. (2017). Reactive oxygen species as mediators of sperm capacitation and pathological damage. Molecular Reproduction and Development, 84(10), 1039-1052. https://doi.org/10.1002/mrd.22871

[4] Aitken, R. J. (2017). Reactive oxygen species as mediators of sperm capacitation and pathological damage. Molecular Reproduction and Development, 84(10), 1039-1052. https://doi.org/10.1002/mrd.22871

[5] Aitken, R. J., & Baker, M. A. (2013). Causes and consequences of apoptosis in spermatozoa; Contributions to infertility and impacts on development. International Journal of Developmental Biology, 57(2-4), 265-272. https://doi.org/10.1387/ijdb.130146ja

[6] Aitken, R. J., & Baker, M. A. (2013). Causes and consequences of apoptosis in spermatozoa; Contributions to infertility and impacts on development. International Journal of Developmental Biology, 57(2-4), 265-272. https://doi.org/10.1387/ijdb.130146ja

[7] Aitken, R. J., Gibb, Z., Baker, M. A., Drevet, J., & Gharagozloo, P. (2016). Causes and consequences of oxidative stress in spermatozoa. Reproduction, Fertility, and Development, 28(1-2), 1-10. https://doi.org/10.1071/rd15325

[8] Aitken, R. J., Gibb, Z., Baker, M. A., Drevet, J., & Gharagozloo, P. (2016). Causes and consequences of oxidative stress in spermatozoa. Reproduction, Fertility, and Development, 28(1-2), 1-10. https://doi.org/10.1071/rd15325

[9] Aitken, R. J., Ross, A., & Lees, M. M. (1983). Analysis of sperm function in Kartagener's syndrome. Fertility and Sterility, 40(5), 696-698. https://doi.org/10.1016/S0015-0282(16)47434-0

[10] Aitken, R. J., Ross, A., & Lees, M. M. (1983). Analysis of sperm function in Kartagener's syndrome. Fertility and Sterility, 40(5), 696-698. https://doi.org/10.1016/S0015-0282(16)47434-0

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Asthenozoospermia: Cellular and molecular contributing factors and treatment strategies

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Asthenozoospermia: Cellular and molecular contributing factors and treatment strategies

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