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. 1988;22(4):321-4.
doi: 10.1007/BF00254239.

Ifosfamide plasma clearance in relation to polymorphic debrisoquine oxidation

P A Philip  1 , L D Lewis, C A James, H J Rogers
Affiliations

Ifosfamide plasma clearance in relation to polymorphic debrisoquine oxidation

P A Philip et al. Cancer Chemother Pharmacol. 1988.

Abstract

Ifosfamide (IF) pharmacokinetics and the plasma (NBP)-alkylating activity were determined in 33 patients with different tumours after the administration of IF as single-agent chemotherapy. All subjects had been phenotyped for debrisoquine oxidation. There is a lack of correlation between the debrisoquine metabolic ratio (DMR) and either the total plasma clearance of IF (CLIF) or the AUC of the plasma NBP-alkylating activity.

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