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Review
. 2019 Oct 31;8(4):205.
doi: 10.3390/antibiotics8040205.

Antitumor Potential of Seaweed Derived-Endophytic Fungi

Thaiz Rodrigues Teixeira  1 , Gustavo Souza Dos Santos  2 , Lorene Armstrong  3 , Pio Colepicolo  4 , Hosana Maria Debonsi  5
Affiliations
Review

Antitumor Potential of Seaweed Derived-Endophytic Fungi

Thaiz Rodrigues Teixeira et al. Antibiotics (Basel). .

Abstract

The marine environment presents a high biodiversity and a valuable source of bioactive compounds with therapeutic and biotechnological potential. Among the organisms present in marine environment, the endophytic fungi isolated from seaweed stand out. These microorganisms have aroused interest in the scientific community regarding its various activities such as antiviral, antimicrobial, antioxidant, photoprotective, cytotoxic, genotoxic, anti-inflammatory, and anticancer, besides establishing important ecological relations with its hosts. Anticancer molecules derived from marine natural sources are a promising target against different types of cancer. The disease's high rates of morbidity and mortality affect millions of people world wild and the search for new therapeutic alternatives is needed. Thus, this review partially summarizes the methodologies for the isolation of seaweed-derived endophytic fungi, as well as describes the anticancer compounds isolated from such microorganisms, reported in the literature from 2009 to the present. In addition, it describes how some biotechnological processes can help in the discovery of bioactive compounds, especially with anticancer activity.

Keywords: Marine Natural Products; cytotoxicity; endophytic fungi; marine biotechnology; seaweed.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of natural products isolated from seaweed derived-endophytic fungi with antitumor potential published from 2009 to 2019.
Figure 1
Figure 1
Chemical structures of natural products isolated from seaweed derived-endophytic fungi with antitumor potential published from 2009 to 2019.
Figure 1
Figure 1
Chemical structures of natural products isolated from seaweed derived-endophytic fungi with antitumor potential published from 2009 to 2019.
Figure 1
Figure 1
Chemical structures of natural products isolated from seaweed derived-endophytic fungi with antitumor potential published from 2009 to 2019.
See this image and copyright information in PMC

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