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Review
. 2019 Nov 1;9(11):679.
doi: 10.3390/biom9110679.

Natural Products and Synthetic Analogs as a Source of Antitumor Drugs

Javad Sharifi-Rad  1 , Adem Ozleyen  2 , Tugba Boyunegmez Tumer  3 , Charles Oluwaseun Adetunji  4 , Nasreddine El Omari  5 , Abdelaali Balahbib  6 , Yasaman Taheri  7   8 , Abdelhakim Bouyahya  9 , Miquel Martorell  10   11 , Natália Martins  12   13 , William C Cho  14
Affiliations
Review

Natural Products and Synthetic Analogs as a Source of Antitumor Drugs

Javad Sharifi-Rad et al. Biomolecules. .

Abstract

Cancer is a heterogeneous disease and one of the major issues of health concern, especially for the public health system globally. Nature is a source of anticancer drugs with abundant pool of diverse chemicals and pharmacologically active compounds. In recent decade, some natural products and synthetic analogs have been investigated for the cancer treatment. This article presents the utilization of natural products as a source of antitumor drugs.

Keywords: anticancer; natural products; phytochemical; phytomedicine.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Classification of the antitumor drugs according to their action mechanism and timeline showing their history.
Figure 2
Figure 2
Chemical structures of cabazitaxel, paclitaxel and docetaxel.
Figure 3
Figure 3
Chemical structures of eribulin and halichondrin B.
Figure 4
Figure 4
Chemical structure of vincristine and formulation of VinCRIStine sulfate liposome injection (Marqibo).
Figure 5
Figure 5
Chemical structures of rucaparib, niraparib, and talazoparib.
Figure 6
Figure 6
The structure of pomalidomide and lenalidomide.
Figure 7
Figure 7
Chemical structures of erdafitinib and lenvatin.
See this image and copyright information in PMC

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