Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project

Pedro Acosta-Manzano^{1

2}, Irene Coll-Risco^{3

4}, Mireille N M Van Poppel⁵, Víctor Segura-Jiménez^{6

7}, Pedro Femia⁸, Lidia Romero-Gallardo^{9

10}, Milkana Borges-Cosic^{11

12}, Javier Díaz-Castro¹³, Jorge Moreno-Fernández¹⁴, Julio J Ochoa-Herrera¹⁵, Virginia A Aparicio^{16

17}

Affiliations

¹ PA-HELP "Physical Activity for Health Promotion, CTS-1018" Research group, Department of Physical Education and Sport, Faculty of Sport Sciences. University of Granada, Granada 18011, Spain. pacostamanzano@gmail.com.
² Sport and Health Research Centre, University of Granada, Granada 18007, Spain. pacostamanzano@gmail.com.
³ Sport and Health Research Centre, University of Granada, Granada 18007, Spain. irecoll@ugr.es.
⁴ Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, University of Granada, Granada 18011, Spain. irecoll@ugr.es.
⁵ Institute of Sport Science, University of Graz, Graz 8010, Austria. mireille.van-poppel@uni-graz.at.
⁶ Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz 11519, Spain. victor.segura@uca.es.
⁷ Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital University of Cádiz, Cádiz 11009, Spain. victor.segura@uca.es.
⁸ Unit of Biostatistics, Department of Statistics, Faculty of Medicine, University of Granada, Granada 18016, Spain. pfemia@ugr.es.
⁹ PA-HELP "Physical Activity for Health Promotion, CTS-1018" Research group, Department of Physical Education and Sport, Faculty of Sport Sciences. University of Granada, Granada 18011, Spain. lidiaromerogallardo@gmail.com.
¹⁰ Sport and Health Research Centre, University of Granada, Granada 18007, Spain. lidiaromerogallardo@gmail.com.
¹¹ PA-HELP "Physical Activity for Health Promotion, CTS-1018" Research group, Department of Physical Education and Sport, Faculty of Sport Sciences. University of Granada, Granada 18011, Spain. milkana@ugr.es.
¹² Sport and Health Research Centre, University of Granada, Granada 18007, Spain. milkana@ugr.es.
¹³ Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, University of Granada, Granada 18011, Spain. javierdc@ugr.es.
¹⁴ Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, University of Granada, Granada 18011, Spain. jorgemf@ugr.es.
¹⁵ Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, University of Granada, Granada 18011, Spain. jjoh@ugr.es.
¹⁶ Sport and Health Research Centre, University of Granada, Granada 18007, Spain. virginiaparicio@ugr.es.
¹⁷ Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, University of Granada, Granada 18011, Spain. virginiaparicio@ugr.es.

PMID: 31684183
PMCID: PMC6912691
DOI: 10.3390/jcm8111862

Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project

Pedro Acosta-Manzano et al. J Clin Med. 2019.

. 2019 Nov 3;8(11):1862.

doi: 10.3390/jcm8111862.

Authors

Affiliations

¹ PA-HELP "Physical Activity for Health Promotion, CTS-1018" Research group, Department of Physical Education and Sport, Faculty of Sport Sciences. University of Granada, Granada 18011, Spain. pacostamanzano@gmail.com.
² Sport and Health Research Centre, University of Granada, Granada 18007, Spain. pacostamanzano@gmail.com.
³ Sport and Health Research Centre, University of Granada, Granada 18007, Spain. irecoll@ugr.es.
⁴ Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, University of Granada, Granada 18011, Spain. irecoll@ugr.es.
⁵ Institute of Sport Science, University of Graz, Graz 8010, Austria. mireille.van-poppel@uni-graz.at.
⁶ Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz 11519, Spain. victor.segura@uca.es.
⁷ Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital University of Cádiz, Cádiz 11009, Spain. victor.segura@uca.es.
⁸ Unit of Biostatistics, Department of Statistics, Faculty of Medicine, University of Granada, Granada 18016, Spain. pfemia@ugr.es.
⁹ PA-HELP "Physical Activity for Health Promotion, CTS-1018" Research group, Department of Physical Education and Sport, Faculty of Sport Sciences. University of Granada, Granada 18011, Spain. lidiaromerogallardo@gmail.com.
¹⁰ Sport and Health Research Centre, University of Granada, Granada 18007, Spain. lidiaromerogallardo@gmail.com.
¹¹ PA-HELP "Physical Activity for Health Promotion, CTS-1018" Research group, Department of Physical Education and Sport, Faculty of Sport Sciences. University of Granada, Granada 18011, Spain. milkana@ugr.es.
¹² Sport and Health Research Centre, University of Granada, Granada 18007, Spain. milkana@ugr.es.
¹³ Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, University of Granada, Granada 18011, Spain. javierdc@ugr.es.
¹⁴ Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, University of Granada, Granada 18011, Spain. jorgemf@ugr.es.
¹⁵ Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, University of Granada, Granada 18011, Spain. jjoh@ugr.es.
¹⁶ Sport and Health Research Centre, University of Granada, Granada 18007, Spain. virginiaparicio@ugr.es.
¹⁷ Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, University of Granada, Granada 18011, Spain. virginiaparicio@ugr.es.

PMID: 31684183
PMCID: PMC6912691
DOI: 10.3390/jcm8111862

Abstract

The aim of the present study was to analyze the influence of a supervised concurrent exercise-training program, from the 17th gestational week until delivery, on cytokines in maternal (at 17th and 35th gestational week, and at delivery) and arterial and venous cord serum. Fifty-eight Caucasian pregnant women (age: 33.5 ± 4.7 years old, body mass index: 23.6 ± 4.1kg/m²) from the GESTAFIT Project (exercise (n = 37) and control (n = 21) groups) participated in this quasi-experimental study (per-protocol basis). The exercise group followed a 60-min 3 days/week concurrent (aerobic-resistance) exercise-training from the 17th gestational week to delivery. Maternal and arterial and venous cord serum cytokines (fractalkine, interleukin (IL)-1β, IL-6, IL-8, IL-10, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α) were assessed using Luminex xMAP technology. In maternal serum (after adjusting for the baseline values of cytokines), the exercise group decreased TNF-α (from baseline to 35th week, p = 0.02), and increased less IL-1β (from baseline to delivery, p = 0.03) concentrations than controls. When adjusting for other potential confounders, these differences became non-significant. In cord blood, the exercise group showed reduced arterial IL-6 and venous TNF-α (p = 0.03 and p = 0.001, respectively) and higher concentrations of arterial IL-1β (p = 0.03) compared to controls. The application of concurrent exercise-training programs could be a strategy to modulate immune responses in pregnant women and their fetuses. However, future research is needed to better understand the origin and clearance of these cytokines, their role in the maternal-placental-fetus crosstalk, and the influence of exercise interventions on them.

Keywords: cytokines; immune; interferon-gamma; interleukin 1B; interleukin 6; tumor necrosis factor.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

**Figure 1**
Flowchart of pregnant women through each stage of the study.

See this image and copyright information in PMC

References

1. Kalagiri R.R., Carder T., Choudhury S., Vora N., Ballard A.R., Govande V., Dreyer N., Beeram M.R., Uddin M.N. Inflammation in Complicated Pregnancy and Its Outcome. Am. J. Perinatol. 2016;33:1337–1356. doi: 10.1055/s-0036-1582397. - DOI - PubMed
1. Mor G., Cardenas I., Abrahams V., Guller S. Inflammation and pregnancy: The role of the immune system at the implantation site. In: Guller S., Bulletti C., DeZiegler D., editors. Reproductive Science. Volume 1221. Blackwell Science Publ; Oxford, UK: 2011. pp. 80–87. - PMC - PubMed
1. Yockey L.J., Iwasaki A. Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development. Immunity. 2018;49:397–412. doi: 10.1016/j.immuni.2018.07.017. - DOI - PMC - PubMed
1. Cheng S.B., Sharma S. Interleukin-10: A Pleiotropic Regulator in Pregnancy. Am. J. Reprod. Immunol. 2015;73:487–500. doi: 10.1111/aji.12329. - DOI - PMC - PubMed
1. Murphy S.P., Tayade C., Ashkar A.A., Hatta K., Zhang J.H., Croy B.A. Interferon Gamma in Successful Pregnancies. Biol. Reprod. 2009;80:848–859. doi: 10.1095/biolreprod.108.073353. - DOI - PMC - PubMed

Grants and funding

LinkOut - more resources

Full Text Sources
Research Materials
- NCI CPTC Antibody Characterization Program

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project

Affiliations

Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Grants and funding

LinkOut - more resources

Full Text Sources

Research Materials