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. 2019 Aug 21:12:205-217.
doi: 10.2147/JIR.S193749. eCollection 2019.

Impact of polyphenols in phagocyte functions

Leandro Rodrigues da Cunha  1 , Maria Imaculada Muniz-Junqueira  1 , Tatiana Karla Dos Santos Borges  1
Affiliations

Impact of polyphenols in phagocyte functions

Leandro Rodrigues da Cunha et al. J Inflamm Res. .

Abstract

Polyphenols are a broad group of substances with potential health benefits found in plant species. Several of these compounds are capable of influencing the activation of intracellular signaling pathways, such as NF-kB, MAPK and JAK-STAT, responsible for the production of various inflammatory mediators such as tumor necrosis factor α (TNF-α) and interleukin 1 beta (IL-1β) and 12 (IL-12), enzymes involved in the production of reactive species such as inducible nitric oxide synthase (iNOS) and superoxide dehydrogenase (SOD), as well as enzymes involved in the production of eicosanoids, such as cyclooxygenase (COX) and lipoxygenase (LO). There is increased interest in the use of polyphenol-rich foods because of their immunomodulatory effect; however, the mechanisms used during macrophage responses are extremely complex and little is known about the effects of polyphenols on these cells. As such, this review summarizes the current view of polyphenol influences on macrophages.

Keywords: cytokine modulation; inflammation; macrophage activation; polyphenols.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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