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. 2019 Oct 10:2019:8410290.
doi: 10.1155/2019/8410290. eCollection 2019.

Genetic Polymorphisms of IFNG and IFNGR1 with Latent Tuberculosis Infection

Shouquan Wu  1 , Xiangmin Liu  1 , Yu Wang  1 , Miaomiao Zhang  1 , Minggui Wang  1 , Jian-Qing He  1
Affiliations

Genetic Polymorphisms of IFNG and IFNGR1 with Latent Tuberculosis Infection

Shouquan Wu et al. Dis Markers. .

Abstract

Previous studies indicated that single-nucleotide polymorphisms (SNPs) of interferon gamma (IFNG) and IFNG receptor 1 (IFNGR1) may be involved in the pathogenesis of pulmonary tuberculosis (PTB) in different populations. In order to further explore the results in a Chinese Han population, this study was designed to investigate potential associations between the polymorphisms in IFNG and IFNGR1 and susceptibility to latent tuberculosis infection (LTBI) and/or PTB in a Chinese Han population. A total of 209 PTB, 173 LTBI, and 183 healthy control subjects (HCS) were enrolled in our study. Genotyping was conducted using an improved multiplex ligase detection reaction (iMLDR). We performed a logistic regression including sex and age as covariates to test the effect of alleles/genotypes on LTBI and/or TB. All six markers studied in IFNG and IFNGR1 conformed to the Hardy-Weinberg equilibrium (HWE). The IFNG rs1861494 was significantly associated with LTBI in recessive model, and the CC+CT genotype decreased risk of LTBI by 50% (P = 0.046, OR = 0.50, 95%CI: 0.25-0.99). The IFNGR1 rs2234711 was significantly associated with LTBI, and allele A increased the risk of LTBI by 55% (P = 0.047, OR = 1.55, 95%CI: 1.00-2.40). In the present study, we found that IFNG and IFNGR1 polymorphisms were associated with LTBI.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Evaluation of IFNG production levels among the LTBI and PTB.
See this image and copyright information in PMC

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