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. 2019 Oct 9:2019:2637607.
doi: 10.1155/2019/2637607. eCollection 2019.

The TNFA -857C/T Polymorphism: Association with Rheumatoid Arthritis and Anti-CCP Levels in a Mexican Population

Juan Manuel Agraz-Cibrián  1 , Gabriela Nohemí Espinoza-De León  1 , Ma de Jesús Durán-Avelar  1 , Norberto Vibanco-Pérez  1 , Liliana Ortiz-Martínez  2 , Alejandro Vázquez-Reyes  1 , Jorge Gutiérrez-Franco  1 , Miriam Fabiola Ayón-Pérez  1 , José Francisco Zambrano-Zaragoza  1
Affiliations

The TNFA -857C/T Polymorphism: Association with Rheumatoid Arthritis and Anti-CCP Levels in a Mexican Population

Juan Manuel Agraz-Cibrián et al. J Immunol Res. .

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease whose association with SNPs has led to the identification of biomarkers in different populations. To determine the association of the -857C/T SNP of the TNFA gene with RA and clinical parameters, 233 RA patients and 237 healthy controls were included in this study. The -857C/T polymorphism was determined using the TaqMan® system and clinical features were also determined. We found that the -857C/T SNP was in Hardy-Weinberg equilibrium. Our results showed no association of the -857C/T SNP with RA; however, RA patients carrying the TT genotype showed lower anti-CCP levels than other groups. Therefore, the TT genotype could be a risk factor for developing anti-CCP-negative RA. Our results suggest that the T allele of the TNFA -857C/T SNP exerts an influence on anti-CCP levels and could be a candidate marker for anti-CCP-negative RA.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Anti-CCP levels in RA patients grouped according to their genotype, -857-C/T. Comparisons were performed using the Mann–Whitney U test.
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