[PHENOTYPIC POLYMORPHISM OF N-ACETYLTRANSFERASE 2 IN PATIENTS WITH DIABETES MELLITUS]

Abstract

Polymorphism of N-acetyltransferase 2 (NAT2) determines the risk of certain diseases and the rate of inactivation of various xenobiotics and drugs. We investigated phenotypic polymorphism of N-acetyltransferase 2 among 141 healthy subjects and 115 patients with type 2 diabetes mellitus. An analysis of the distribution of genetic determinants, depending on the acetylation status, was carried out. The bimodal distribution of the phenotypic polymorphism of NAT 2 activity was revealed among diabetic patients and healthy individuals. There was no gender difference in NAT2 activity in both groups of subjects. Genetic analysis showed a prevalence of brown-eyed diabetic patients compared to blue-eyed persons among fast acetylators. Among diabetic patients prevailed subjects with dimples on the chin and cheeks and the enlarged ear lobe as well as the reduced proportion of patients with the ability to twist the tongue into a tube compared to healthy individuals. There was a significantly increased proportion of black-haired persons among diabetic patients compared to healthy individuals. Acetylation phenotype prediction scale developed was developed, which allows determining the acetylator status without biochemical intervention, but using anthropometric indicators.