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Review
. 2020 Mar;26(2):162-168.
doi: 10.1097/MCP.0000000000000637.

Small airway disease in chronic obstructive pulmonary disease: insights and implications for the clinician

Dave Singh  1   2 , Gabriella Long  2 , José E D Cançado  3 , Andrew Higham  1
Affiliations
Review

Small airway disease in chronic obstructive pulmonary disease: insights and implications for the clinician

Dave Singh et al. Curr Opin Pulm Med. 2020 Mar.

Abstract

Purpose of review: Small airway disease (SAD) is a common feature in chronic obstructive pulmonary disease (COPD) patients. Chronic exposure to cigarette smoking causes inflammation, damage, tissue remodelling and eventually airway loss. These features lead to airflow limitation and defective alveolar ventilation. The aim of this review is to provide clinicians with an up-to-date perspective of SAD in COPD.

Recent findings: In this review, we will discuss the key pathological features of SAD. We also review state-of-the-art techniques for measuring SAD, including impulse oscillometry and lung imaging methods. We discuss emerging concepts such as SAD in the earlier stages of COPD and the relationship between SAD and emphysema.

Summary: The current review highlights the importance of targeting small airways early in the course of COPD to tackle disease progression.

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References

    1. Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report: GOLD executive summary. Eur Respir J 2017; 49:214–239.
    1. Singh D, Roche N, Halpin D, et al. Current controversies in the pharmacological treatment of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2016; 194:541–549.
    1. Weibel ER. Morphometry of the human lung. 1963; New York: Academic Press Inc, 110–135.
    1. Stuart BO. Deposition and clearance of inhaled particles. Environ Health Perspect 1984; 55:369–390.
    1. Cosio MG, Hale KA, Niewoehner DE. Morphologic and morphometric effects of prolonged cigarette smoking on the small airways. Am Rev Respir Dis 1980; 122:265–321.

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