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. 2019 Sep 19;9(4):1383-1410.
doi: 10.1002/cphy.c180018.

Neuroendocrine Regulation of Male Sexual Behavior

Elaine M Hull  1 , Juan M Dominguez  2
Affiliations

Neuroendocrine Regulation of Male Sexual Behavior

Elaine M Hull et al. Compr Physiol. .

Abstract

The major brain areas that control males' sexual motivation and performance include the amygdala, the bed nucleus of the stria terminalis (BNST), the medial preoptic area (MPOA), and paraventricular nucleus (PVN) of the hypothalamus, as well as the mesolimbic dopamine (DA) system. The MPOA, PVN, and brain stem and spinal nuclei control the genital reflexes. Sensory and motor aspects are integrated and elicited by the amygdala, BNST, MPOA, PVN, and the mesolimbic and nigrostriatal DA tracts, which are integral for other social behaviors, as well. Developmental hormonal effects organize the network to elicit specific behaviors, which are activated by those hormones in adolescence and adulthood. Steroid hormones primarily work through slow genomic mechanisms that increase enzymes, receptors, or structural proteins, although they may also activate membrane receptors for rapid effects. © 2019 American Physiological Society. Compr Physiol 9:1383-1410, 2019.

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References

    1. Adachi H, Sato Y, Kato R, Hisasue S, Suzuki K, Masumori N, Itoh N, Tsukamoto T. Direct evidence of facilitative actions of dopamine in the medial preoptic area on reflexive and noncontact erections in male rats. J Urol 169: 386-389, 2003.
    1. Ågmo A, Ellingsen E. Relevance of non-human animal studies to the understanding of human sexuality. Scand J Psychol 44: 293-301, 2003.
    1. Ågmo A, Soulairac M-L, Soulairac A. Preoptic lesions, sexual behavior, and spontaneous ejaculation in the rat. Scand J Psychol 18: 345-347, 1977.
    1. Alderson LM, Baum MJ. Differential effects of gonadal steroids on dopamine metabolism in mesolimbic and nigro-striatal pathways of male rat brain. Brain Res 218: 189-206, 1981.
    1. Alexander BM, Perkins A, Van Kirk EA, Moss GE, Fitzgerald JA. Hypothalamic and hypophyseal receptors for estradiol in high and low sexually performing rams. Horm Behav 27: 296-307, 1993.

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