Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review

Adverse Drug Reaction Probability Scale (Naranjo) in Drug Induced Liver Injury

No authors listed
In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012.
.
Free Books & Documents
Review

Adverse Drug Reaction Probability Scale (Naranjo) in Drug Induced Liver Injury

No authors listed.
Free Books & Documents
No abstract available

PubMed Disclaimer

References

    1. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, et al. A method for estimating the probability of adverse drug reactions. Clin Pharacol Ther. 1981;30:239–45. [ (Initial description of Naranjo system for assessing adverse drug reactions, giving -1 to +2 points for 10 items: prevous conclusive reports, time of onset, improvement on stopping, reappearance with reexposure, alternative causes, reappearance with placebo, drug levels, dose response, previous exposure and history, and confirmation by objective evidence with total scores that range from -4 to +13; kappa=0.64 to 0.71 in assessing 63 cases by 3 authors). ] - PubMed
    1. Busto U, Naranjo CA, Sellers EM. Comparison of two recently published algorithms for assessing the probability of adverse drug reactions. Br J Clin Pharmacol. 1982;13:223–7. [ (Comparison of two scales for adverse drug reactions found both to have interreviewer reliability of >95%, but the Naranjo scale was easier and faster to fill out). ] - PMC - PubMed
    1. Naranjo CA, Busto U, Sellers EM. Difficulties in assessing adverse drug reactions in clinical trials. Prog Neuropsychopharmacol Biol Psychiatry. 1982;6:651–7. [ (Overview on the difficulties of assessing adverse drug reactions and assigning severity and causality scores). ] - PubMed
    1. Garcia-Cortes M, Lucena MI, Pachkoria K, Borraz Y, Hidalgo R, Andrade RJ, Spanish Group for the Study of Drug-Induced Liver Disease Evaluation of Naranjo adverse drug reactions probability scale in causality assessment of drug-induced liver injury. Aliment Pharmacol Ther. 2008;27:780–9. [ (Two reviewers evaluated 225 cases of suspected hepatotoxicity from the Spanish database using two causality scales; there was interreviewer agreement in only 45%, and kappa=0.17 for Naranjo compared to 72% and kappa=0.71 for RUCAM; the Naranjo scale had a low sensitivity [54%] and poor negative predictive value [29%]). ] - PubMed

LinkOut - more resources