Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Nov 4;51(3):293-294.
doi: 10.1016/j.devcel.2019.10.015.

Diving Deep into the Adult Mouse Kidney

Affiliations
Comment

Diving Deep into the Adult Mouse Kidney

Melissa H Little. Dev Cell. .

Abstract

In this issue of Developmental Cell, Ransick et al. (2019) provide a comprehensive anatomically guided single-cell dataset from adult mouse kidney, representing the most detailed analysis of the cellular heterogeneity and lineage relationship of cells in the adult mouse kidney published to date.

PubMed Disclaimer

Figures

Figure
Figure
The Kidney Cell Explorer interface allows gene by gene searching of the adult mouse kidney with the relative expression presented within a diagrammatic representation of both cortical and juxtamedullary nephrons, including a display of male verus female differences within proximal tubule clusters.

Comment on

References

    1. Brunskill EW, Aronow BJ, Georgas K, Rumballe B, Valerius MT, Aronow J, Kaimal V, Jegga AG, Yu J, Grimmond S, McMahon AP, Patterson LT, Little MH, Potter SS. Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell. 2008. 15(5):781–91 - PMC - PubMed
    1. Brunskill EW, Park JS, Chung E, Chen F, Magella B, Potter SS. Single cell dissection of early kidney development: multilineage priming. Development. 2014. 141(15):3093–101. - PMC - PubMed
    1. Georgas K, Rumballe B, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, Taylor D, Grimmond SM, Potter SS, McMahon AP, Little MH. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol. 2009. 332(2):273–86 - PubMed
    1. Lindström NO, Tran T, Guo J, Rutledge E, Parvez RK, Thornton ME, Grubbs B, McMahon JA, McMahon AP. Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning. J Am Soc Nephrol. 2018. 29(3):825–840. - PMC - PubMed
    1. Park J, Shrestha R, Qiu C, Kondo A, Huang S, Werth M, Li M, Barasch J, Suszták K. Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. Science. 2018. 360(6390):758–763. - PMC - PubMed

LinkOut - more resources