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. 2019 Nov 5;19(1):119.
doi: 10.1186/s12902-019-0446-4.

The shape of the glucose response curve during an oral glucose tolerance test heralds β-cell function in a large Chinese population

Xinqi Cheng  1 , Na Yang  2 , Yuxiu Li  2 , Qi Sun  2 , Ling Qiu  1 , Lingling Xu  2 , Fan Ping  2 , Wei Li  2 , Huabing Zhang  3
Affiliations

The shape of the glucose response curve during an oral glucose tolerance test heralds β-cell function in a large Chinese population

Xinqi Cheng et al. BMC Endocr Disord. .

Abstract

Background: The shape of the glucose response curve during an oral glucose tolerance test (OGTT) can predict β-cell function and insulin resistance. However, there have been few studies conducted on Chinese people. Thus, we aimed to verify the usefulness of the glucose response curve in a large Chinese population.

Methods: A total of 9059 OGTT (3-h tests) were categorized into either a monophasic or a multiphasic group based on the shape of the glucose response. Homeostasis model assessments of fasting insulin resistance, the Matsuda Index, the insulinogenic index, and the disposition index were assessed by plasma glucose and serum insulin concentration obtained at fasting or during an OGTT.

Results: The shape of the OGTT glucose response curve was monophasic in 87.3% and multiphasic in 12.7% of participants. Individuals in the multiphasic group were younger compared to those in the monophasic group (38.6 ± 13.6 vs. 35.4 ± 13.5, P < 0.001). Individuals in the monophasic group had significantly higher fasting plasma glucose (FPG 5.6 ± 13.5 vs. 5.2 ± 0.6, P < 0.001), fasting insulin (FINS 14.8 ± 8.7 vs. 13.5 ± 7.9, P < 0.01), and homeostasis model assessment of insulin resistance (HOMA-IR 3.8 ± 2.6 vs. 3.1 ± 2.0, P < 0.001) and impaired β-cell function (disposition index 12.7 ± 14.1 vs. 16.6 ± 17.8, P < 0.001) compared to those in the multiphasic group.

Conclusion: The monophasic OGTT glucose response curve could reflect impaired β-cell function in a large Chinese population.

Keywords: Chinese; Glucose response curve; OGTT.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Study Flow Diagram OGTT: oral glucose tolerance test
Fig. 2
Fig. 2
Glucose during a 3-h OGTT in monophasic, biphasic and triphasic groups among different glycemic status. NGT: normal glucose tolerance, DM: diabetes mellitus
Fig. 3
Fig. 3
Proportion of multiphasic curves at different age group and glycemic status NGT: normal glucose tolerance, DM: diabetes mellitus
See this image and copyright information in PMC

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