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. 2019 Nov 6;19(1):15.
doi: 10.1186/s12895-019-0095-3.

Validation of the Atopic Dermatitis Control Tool (ADCT©) using a longitudinal survey of biologic-treated patients with atopic dermatitis

Eric Simpson  1 , Laurent Eckert  2 , Abhijit Gadkari  3 , Usha G Mallya  4 , Min Yang  5 , Lauren Nelson  6 , Michelle Brown  6 , Matt Reaney  7 , Puneet Mahajan  8 , Isabelle Guillemin  9 , Mark Boguniewicz  10 , David Pariser  11
Affiliations

Validation of the Atopic Dermatitis Control Tool (ADCT©) using a longitudinal survey of biologic-treated patients with atopic dermatitis

Eric Simpson et al. BMC Dermatol. .

Abstract

Background: The Atopic Dermatitis Control Tool (ADCT©) is a brief patient self-administered instrument designed and validated to assess atopic dermatitis (AD) control; six AD symptoms and impacts are evaluated over the past week, including overall severity of symptoms, days with intense episodes of itching, intensity of bother, problem with sleep, impact on daily activities, and impact on mood or emotions. This study assessed the reliability, validity, and responsiveness of the ADCT in a longitudinal context, and provided thresholds to identify meaningful within-person change.

Methods: Data were from a prospective, longitudinal patient survey study of real-world effectiveness of dupilumab in patients with AD. Eligible patients completed a baseline survey before starting dupilumab and were followed at Months 1, 2, 3, and 6 post-initiation as they became eligible.

Results: Psychometric analyses confirmed internal consistency; Cronbach's α coefficients were consistently above the threshold of 0.70 across each follow-up; item-to-total correlations were above the threshold of r ≥ 0.50. High correlations between the ADCT and the Dermatology Life Quality Index (DLQI) and skin pain supported construct validity, while known-group validity was shown on Patient Global Assessment of Disease (PGAD) overall well-being subgroups with worse AD-related overall well-being having higher mean ADCT total scores at all time points. The ability of the ADCT to detect change was confirmed; the threshold for meaningful within-person change was estimated to be 5 points. Finally, test-retest reliability was confirmed in subgroups of patients with stable PGAD responses.

Conclusions: Our findings confirm that the ADCT is a valid and reliable tool for assessing AD control.

Keywords: ADCT©; Atopic dermatitis, tool, control, symptoms, impacts; reliability; responsiveness; validity.

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Conflict of interest statement

L. Eckert, M. Reaney, I Guillemin, U.G. Mallya, and P. Mahajan are employees and shareholders of Sanofi. A. Gadkari is an employee and shareholder of Regeneron. M. Yang is an employee of the Analysis Group, Inc. which received research funding for the current study. L. Nelson and M. Brown are employees of RTI Health Solutions, which received research funding for the current study. E.L. Simpson has received grants/research support from Amgen, Celgene, Chugai, Galderma, and Regeneron Pharmaceuticals Inc., and is a consultant for Anacor, Asubio, Celgene, Galderma, Genentech, Medicis, and Merck. D.M. Pariser has been a consultant to Abbott Laboratories, Amgen, Asana, Biosciences, LLC, Atacama Therapeutics, Bickel Biotechnology, Biofrontera AG, Celgene Corporation, Dermira, Dermavant Sciences, DUSA Pharmaceuticals, Inc., Eli Lilly and Company, LEO Pharma, US, Merck & Co., Inc., Novartis Pharmaceuticals Corp., Novo Nordisk A/S, Ortho Dermatologics, Peplin Inc., Pfizer Inc., Photocure ASA, Promius Pharmaceuticals, Regeneron Pharmaceuticals, Inc., Sanofi, Stiefel a GSK company, TDM SurgiTech, Inc., TheraVida, Valeant Pharmaceuticals International. M Boguniewicz has received grants from Regeneron Pharmaceuticals, Inc. and has been a consultant for Regeneron Pharmaceuticals, Inc. and Sanofi-Genzyme.

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