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Review
. 2020 Mar;91(3):e12846.
doi: 10.1111/sji.12846. Epub 2019 Nov 24.

The CCL20 and CCR6 axis in psoriasis

Kazuhisa Furue  1 , Takamichi Ito  1 , Gaku Tsuji  2 , Takeshi Nakahara  3 , Masutaka Furue  1   2   3
Affiliations
Free article
Review

The CCL20 and CCR6 axis in psoriasis

Kazuhisa Furue et al. Scand J Immunol. 2020 Mar.
Free article

Abstract

Psoriasis is a TNF-α/IL-23/IL-17A-mediated inflammatory skin disease that causes a significant socioeconomic burden in afflicted patients. IL-17A-producing immune cells, including Th17 cells, are crucial effector cells in the development of psoriasis. IL-17A stimulates epidermal keratinocytes to produce CCL20, which eventually recruits CCR6 + Th17 cells into the lesional skin. Thus, the CCL20/CCR6 axis works as a driving force that prepares an IL-17A-rich cutaneous milieu. In this review, we summarize the current research topics on the CCL20/CCR6 axis and the therapeutic intervention of this axis for psoriasis.

Keywords: CCL20; CCR6; Koebner phenomenon; Th17; psoriasis.

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References

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