Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Aug 20;26(9):1377-1382.
doi: 10.1093/ibd/izz265.

Cost Burden of Crohn's Disease and Ulcerative Colitis in the 10-Year Period Before Diagnosis-A Danish Register-Based Study From 2003-2015

Affiliations

Cost Burden of Crohn's Disease and Ulcerative Colitis in the 10-Year Period Before Diagnosis-A Danish Register-Based Study From 2003-2015

Kasper Vadstrup et al. Inflamm Bowel Dis. .

Abstract

Background: The diagnostic delay in inflammatory bowel disease (IBD) is well known, yet the costs associated with diagnoses before IBD diagnosis have not yet been reported. This study explored societal costs and disease diagnoses 10 years before Crohn's disease (CD) and ulcerative colitis (UC) diagnosis in Denmark.

Methods: This national register study included patients diagnosed between 2003 and 2015 identified in the Danish National Patient Registry (NPR) and controls who were individually matched on age and sex from the general population. Societal costs included health care services, prescription medicine, home care services, and labor productivity loss. Prediagnostic hospital contact occurring before CD or UC diagnosis was identified using the NPR. Average annual costs per individual were calculated before the patient's first CD or UC diagnosis. A 1-sample t test was then applied to determine significance in differences between cases and controls.

Results: Among CD (n = 9019) and UC patients (n = 20,913) the average societal costs were higher throughout the entire 10-year period before the diagnosis date compared with the general population. The difference increased over time and equaled €404 for CD patients and €516 for UC patients 10 years before diagnosis and €3377 and €2960, respectively, in the year before diagnosis. Crohn's disease and UC patients had significantly more diagnoses before their CD and UC diagnosis compared with the general population.

Conclusions: Compared with the general population, the societal costs and number of additional diagnoses among CD and UC patients were substantially higher in the 10-year period before diagnosis.

Keywords: inflammatory bowel disease; registry study; societal costs.

PubMed Disclaimer

Figures

FIGURE 1.
FIGURE 1.
Flowchart of study population.
FIGURE 2.
FIGURE 2.
Average individual costs during the 10-year period before CD/UC diagnosis.
FIGURE 3.
FIGURE 3.
Average individual labor production value before CD/UC diagnosis. Prices in Euros 2016.
FIGURE 4.
FIGURE 4.
Difference in average individual costs between cases and controls by cost type, CD. Prices in Euros 2016.
FIGURE 5.
FIGURE 5.
Difference in average individual costs between cases and controls by cost type, UC. Prices in Euros 2016.

References

    1. Gyires K, Tóth ÉV, Zádori SZ. Gut inflammation: current update on pathophysiology, molecular mechanism and pharmacological treatment modalities. Curr Pharm Des. 2014;20:1063–1081. - PubMed
    1. Ko JK, Auyeung KK. Inflammatory bowel disease: etiology, pathogenesis and current therapy. Curr Pharm Des. 2014;20:1082–1096. - PubMed
    1. Clearfield HR. How does IBD affect quality of life? Inflamm Bowel Dis. 2008;14(Suppl 2):S45–S46. - PubMed
    1. Vavricka SR, Schoepfer A, Scharl M, et al. . Extraintestinal manifestations of inflammatory bowel disease. Inflamm Bowel Dis. 2015;21:1982–1992. - PMC - PubMed
    1. Nguyen VQ, Jiang D, Hoffman SN, et al. . Impact of diagnostic delay and associated factors on clinical outcomes in a U.S. inflammatory bowel disease cohort. Inflamm Bowel Dis. 2017;23:1825–1831. - PubMed

Publication types