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Comment
. 2019 Nov 5;30(5):852-854.
doi: 10.1016/j.cmet.2019.10.002.

A Gut Check Explains Improved Glucose Metabolism after Surgery

Blandine Laferrère  1 , François Pattou  2
Affiliations
Comment

A Gut Check Explains Improved Glucose Metabolism after Surgery

Blandine Laferrère et al. Cell Metab. .

Abstract

Biliopancreatic diversion (BPD) surgery leads to more frequent diabetes remission than Roux-en-Y gastric bypass (RYGB). In this issue, Harris et al. (2019) compare each surgery after careful matching for percentage weight loss and find the gut as a major site of difference between the effects of the two surgeries.

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Figures

Figure 1.
Figure 1.. Gastrointestinal Diversion Blunts Intestinal Absorption of Glucose by Reducing Intestinal Sodium-Glucose Co-transport Activity
Ingested food travels in the absence of the endogenous sodium contained in bile and pancreatic juice (Baud et al., 2016). This effect is inversely proportional to the length of the common channel and therefore maximal in biliopancreatic diversion.
See this image and copyright information in PMC

Comment on

References

    1. Baud G, Daoudi M, Hubert T, Raverdy V, Pigeyre M, Hervieux E, Devienne M, Ghunaim M, Bonner C, Quenon A, et al. (2016). Bile diversion in Roux-en-Y gastric bypass modulates sodium-dependent glucose intestinal uptake. Cell Metab. 23, 547–553. - PubMed
    1. Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Pettiti M, Natali A, Mari A, and DeFronzo RA (2003). Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance. Diabetologia 46, 1211–1219. - PubMed
    1. Greco AV, Mingrone G, Giancaterini A, Manco M, Morroni M, Cinti S, Granzotto M, Vettor R, Camastra S, and Ferrannini E (2002). Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion. Diabetes 51, 144–151. - PubMed
    1. Harris L-A, Kayser BD, Cefalo C, Marini L, Watrous JD, Ding J, Jain M, McDonald JG, Thompson BM, Fabbrini E, et al. (2019). Biliopancreatic diversion induces greater metabolic improvement than Roux-en-Y gastric bypass. Cell Metab. 30, this issue, 855–864. - PMC - PubMed
    1. Laferrère B, and Pattou F (2018). Weight-independent mechanisms of glucose control after Roux-en-Y gastric bypass. Front. Endocrinol. (Lausanne) 9, 530. - PMC - PubMed