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Randomized Controlled Trial
. 2019 Nov 5;11(11):2671.
doi: 10.3390/nu11112671.

Effects of Zinc Supplementation on Nutritional Status in Children with Chronic Kidney Disease: A Randomized Trial

Marlene Fabiola Escobedo-Monge  1   2   3 , Guido Ayala-Macedo  1 , Graciela Sakihara  2 , Silvia Peralta  4 , Ana Almaraz-Gómez  5 , Enrique Barrado  6 , J M Marugán-Miguelsanz  7
Affiliations
Randomized Controlled Trial

Effects of Zinc Supplementation on Nutritional Status in Children with Chronic Kidney Disease: A Randomized Trial

Marlene Fabiola Escobedo-Monge et al. Nutrients. .

Abstract

Background: Zinc is an essential micronutrient for human beings and its deficiency affects their normal growth and development.

Objective: The main aim was to evaluate the effect of two doses of zinc supplementation (ZS) on the nutritional status in chronic kidney disease (CKD) children.

Methods: A randomized-trial multicentric study was conducted in 48 CKD (23 females) patients under 18-years-old, for a year. At random, participants took 30 or 15 mg/day of ZS, respectively. Anthropometric measurements and biochemical analysis were performed. Hypozincemia was determined by serum zinc concentration (SZC) using atomic absorption spectrophotometry. The positive or negative change in patients' body mass index (BMI) Z-score, serum albumin, zinc and C-reactive protein (CRP) levels were used to evaluate the effect of ZS.

Results: Mean SZC was normal before and after ZS. Despite ZS, there were no significant changes in serum albumin, zinc and CRP levels. A positive and significant association was observed between SZC and serum albumin before (p = 0.000) and after (p = 0.007) ZS. In both groups of ZS, there was a small but positive and significant change in body mass and normalization in BMI Z-score, hypoalbuminemia, hypozincemia and high CRP, especially with 30 mg/day of ZS.

Conclusions: Zinc supplementation may be beneficial for nutritional status in children and adolescents with CKD.

Keywords: C-reactive protein; chronic kidney disease; hypozincemia; serum albumin; serum zinc concentration; stunted growth; undernutrition; underweight.

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Conflict of interest statement

The authors declare no conflict of interest. CONCYTEC supported this research project, but they had no role in the design, execution, interpretation, or writing of the study.

Figures

Figure 1
Figure 1
Flow diagram the effect of two doses of zinc supplementation on nutritional status in children with chronic kidney disease.
Figure 2
Figure 2
Linear regression analysis of serum zinc and albumin concentration before zinc supplementation.
Figure 3
Figure 3
Linear regression analysis of serum zinc and albumin concentration after zinc supplementation.
Figure 4
Figure 4
Percentage of cases with positive (+) or negative (−) change by groups of zinc supplementation. BMI: body mass index, W/A: weight-for-age, H/A: height-for-age, CRP: C-reactive protein, Albumin; serum albumin level, Zinc: serum zinc concentration.
See this image and copyright information in PMC

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