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Randomized Controlled Trial
. 2019 Nov 5;16(21):4291.
doi: 10.3390/ijerph16214291.

Effects of Endurance and Endurance-Strength Training on Endothelial Function in Women with Obesity: A Randomized Trial

Marzena Ratajczak  1 , Damian Skrypnik  2 , Paweł Bogdański  2 , Edyta Mądry  3 , Jarosław Walkowiak  4 , Monika Szulińska  2 , Janusz Maciaszek  5 , Matylda Kręgielska-Narożna  2 , Joanna Karolkiewicz  6
Affiliations
Randomized Controlled Trial

Effects of Endurance and Endurance-Strength Training on Endothelial Function in Women with Obesity: A Randomized Trial

Marzena Ratajczak et al. Int J Environ Res Public Health. .

Abstract

Some investigations have demonstrated that a combined endurance-strength training is the most effective in the treatment of obesity. The aim of the research was to access how different trainings influence: endothelial function, lipid metabolism, and risk of atherosclerosis in women with obesity. In a randomized trial, 39 obese women aged 28-62 completed endurance (n = 22, 60-80% HRmax) or combined training (n = 17, 20 minutes of strength exercises, 50-60% 1RM and 25 minutes of endurance training, 60-80% HRmax). Before and after the intervention vascular endothelial function (endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF), thiobarbituric acid reactive substances (TBARS), blood total antioxidant capacity (TAC)), total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and C-reactive protein (CRP)as well as visceral adiposity index (VAI), total-body skeletal muscle mass and atherogenic index of plasma (AIP) were determined. After the trainings, in both groups total cholesterol and total-body skeletal muscle mass increased (p < 0.05). In the group undergoing combined training, lower (p < 0.05) VAI, AIP, CRP and LDL-C were noted. In the group undergoing endurance training TBARS concentration decreased (p < 0.01), while the HDL-C (p < 0.01) concentration as well as eNOS (p < 0.05) activity increased. No significant differences between groups were found, either before or after the programs. Both training programs led to the improvement of lipid metabolism, but only endurance training alone favorably changed indicators of endothelial functions in women with obesity.

Keywords: atherosclerosis; lipid metabolism; physical training; skeletal muscle mass.

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Conflict of interest statement

The authors declare no conflicts of interest. The sponsors had no role in the design, execution, interpretation, or writing of the study.

Figures

Figure 1
Figure 1
Correlation between resting diastolic blood pressure (DBP) and thiobarbituric acid reactive substances (TBARS) concentration in women with obesity before endurance training.
Figure 2
Figure 2
Correlation between resting diastolic blood pressure (DBP) and thiobarbituric acid reactive substances (TBARS) concentration in women with obesity after endurance training.
Figure 3
Figure 3
Correlation between resting systolic blood pressure (SBP) and thiobarbituric acid reactive substances (TBARS) concentration in women with obesity before the combined training.
See this image and copyright information in PMC

References

    1. Van Gaal L.F., Mertens I.L., De Block C.E. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444:875–880. doi: 10.1038/nature05487. - DOI - PubMed
    1. Meyers M.R., Gokce N. Endothelial dysfunction in obesity: Etiological role in atherosclerosis. Curr. Opin. Endocrinol Diabetes Obes. 2007;14:365–369. doi: 10.1097/MED.0b013e3282be90a8. - DOI - PubMed
    1. Guthikonda S., Sinkey C.A., Haynes W.G. What is the most appropriate methodology for detection of conduit artery endothelial dysfunction? Arter. Thromb. Vasc. Biol. 2007;27:1172–1176. doi: 10.1161/ATVBAHA.106.131011. - DOI - PubMed
    1. Giustarini D., Rossi R., Milzani A., Dalle-Donne I. Nitrite and nitrate measurement by Griess reagent in human plasma: Evaluation of interferences and standardization. Methods Enzym. 2008;440:361–380. doi: 10.1016/S0076-6879(07)00823-3. - DOI - PubMed
    1. Gielen S., Schuler G., Adams V. Cardiovascular effects of exercise training: Molecular mechanisms. Circulation. 2010;122:1221–1238. doi: 10.1161/CIRCULATIONAHA.110.939959. - DOI - PubMed

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