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. 2019 Dec 7;17(45):9698-9702.
doi: 10.1039/c9ob02074h. Epub 2019 Nov 7.

Visible-light-mediated direct C3-arylation of 2H-indazoles enabled by an electron-donor-acceptor complex

Kim Christopher C Aganda  1 , Junyoung Kim  2 , Anna Lee  3
Affiliations

Visible-light-mediated direct C3-arylation of 2H-indazoles enabled by an electron-donor-acceptor complex

Kim Christopher C Aganda et al. Org Biomol Chem. .

Abstract

A mild visible-light-mediated, photocatalyst-free arylation of 2H-indazoles was developed. The formation of an electron donor-acceptor complex by 2H-indazoles and aryl diazonium salts in the presence of pyridine allows the direct arylation of 2H-indazoles under visible-light irradiation. This process provides an efficient route for the synthesis of C3-arylated-2H-indazoles, which are important scaffolds of various bioactive compounds.

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