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. 2020 Jan;35(1):59-61.
doi: 10.1002/jca.21757. Epub 2019 Nov 7.

Heparin-induced thrombocytopenia associated with collection of hematopoietic progenitor cells by apheresis

Jay S Raval  1 , Yara A Park  1 , Irina Perjar  1 , Marshall A Mazepa  1 , Benjamin G Vincent  2 , Alice D Ma  2 , Marian A Rollins-Raval  1
Affiliations

Heparin-induced thrombocytopenia associated with collection of hematopoietic progenitor cells by apheresis

Jay S Raval et al. J Clin Apher. 2020 Jan.

Abstract

Heparin-induced thrombocytopenia (HIT) can occur following exposure to heparin and is characterized by thrombocytopenia with increased risk for thrombosis. This condition is mediated by formation of immunoglobulin G antibodies against platelet factor 4/heparin complexes that can subsequently lead to platelet activation. Herein, we detail the clinical and laboratory findings, treatments, and outcomes of two patients who developed HIT and thrombosis after undergoing collection of hematopoietic progenitor cells by apheresis (HPC-A) for autologous HPC transplant. Given that heparin may be used during HPC-A collections, these cases emphasize the importance of prompt consideration of HIT in patients that develop thrombocytopenia and thrombosis following HPC-A collection with heparin anticoagulation.

Keywords: HIT; apheresis; stem cell collection; thrombocytopenia; thrombosis.

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References

REFERENCES

    1. Greinacher A. Heparin-induced thrombocytopenia. N Engl J Med. 2015;373(19):1883-1884.
    1. Salter BS, Weiner MM, Trinh MA, et al. Heparin-induced thrombocytopenia: a comprehensive clinical review. J Am Coll Cardiol. 2016;67(21):2519-2532.
    1. Ohman EM, Granger CB, Rice L, et al. Identification, diagnosis and treatment of heparin-induced thrombocytopenia and thrombosis: a registry of prolonged heparin use and thrombocytopenia among hospitalized patients with and without cardiovascular disease. The complication after thrombocytopenia caused by heparin (CATCH) registry steering committee. J Thromb Thrombolysis. 2005;19(1):11-19.
    1. Warkentin TE, Roberts RS, Hirsh J, Kelton JG. An improved definition of immune heparin-induced thrombocytopenia in postoperative orthopedic patients. Arch Intern Med. 2003;163(20):2518-2524.
    1. Lo GK, Juhl D, Warkentin TE, Sigouin CS, Eichler P, Greinacher A. Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings. J Thromb Haemost. 2006;4(4):759-765.

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