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. 2020 Aug;92(8):1283-1289.
doi: 10.1002/jmv.25624. Epub 2019 Nov 18.

The papillomavirus E5 gene does not affect EGFR transcription and overall survival in cervical cancer

Diogo Lisbôa Basto  1   2 , Cláudia Bessa Pereira Chaves  3 , Shayany Pinto Felix  2 , Sérgio Menezes Amaro-Filho  2 , Valdimara Corrêa Vieira  4   5 , Luís Felipe Leite Martins  6 , Neile Alves de Carvalho  6 , Liz Maria Almeida  6 , Miguel Ângelo Martins Moreira  2
Affiliations

The papillomavirus E5 gene does not affect EGFR transcription and overall survival in cervical cancer

Diogo Lisbôa Basto et al. J Med Virol. 2020 Aug.

Abstract

Introduction: The human papillomavirus (HPV) E5 gene encodes a small and highly hydrophobic oncoprotein that affects immune evasion, cell proliferation, loss of apoptotic capacity and angiogenesis in tumors. E5 shows an affinity for biological membranes and was associated with an increase of epidermal growth factor/epidermal growth factor receptor (EGF/EGFR) signaling through the accumulation of EGFR in cellular membranes. Due to the frequent integration of the HPV genome into the host cell genome, E5 is frequently not transcribed in cervical tumors.

Aim: In this study we looked forward to verifying whether the potential expression of E5 protein in human papillomavirus 16 positive (HPV16+ ) and human papillomavirus 18 positive (HPV18+ ) cervical tumors was associated with levels of EGFR and vascular endothelial growth factor A (VEGFA) transcription and with patients overall survival.

Results: Association between the presence of E5 transcripts and viral genome disruption was observed for HPV16+ and HPV18+ tumors. Association was not observed between tumors potentially capable of translating E5 and EGFR or VEGFA transcriptional levels. Similarly, the capability of translating E5 and overall survival in patients with HPV16+ squamous cell carcinoma tumors stage ≥ IB2 were not associated.

Conclusion: The likely presence of E5 transcripts was neither associated to a higher activity of the EGFR-VEGFA pathway nor to the overall survival of patients with HPV16+ squamous cell carcinoma in stages ≥ IB2.

Keywords: E5 oncogene; HPV16; HPV18; cervical cancer; epidermal growth factor receptor; human papillomavirus; vascular endothelial growth factor.

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References

REFERENCES

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. https://doi.org/10.3322/caac.21492
    1. Instituto Nacional do Câncer José Alencar Gomes da Silva. Atlas de Mortalidade, 2014. https://mortalidade.inca.gov.br/MortalidadeWeb/. Accessed July 24, 2019.
    1. Arroyo LS Human reference clones, 2019. https://www.hpvcenter.se/human_reference_clones/. Accessed July 24, 2019.
    1. Muñoz N, Bosch FX, de Sanjosé S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348(6):518-527. https://doi.org/10.1056/NEJMoa021641.
    1. Walboomers JMM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189(1):12-19. https://doi.org/10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431&...

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