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. 2019 Dec 26;134(26):2339-2345.
doi: 10.1182/blood.2019001821.

Brentuximab vedotin in the treatment of CD30+ PTCL

Stefan K Barta  1 , Jerald Z Gong  2 , Pierluigi Porcu  3
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Free article

Brentuximab vedotin in the treatment of CD30+ PTCL

Stefan K Barta et al. Blood. .
Free article

Abstract

The development of brentuximab vedotin has opened a new era in the management of peripheral T-cell lymphomas (PTCLs). The improved outcomes with brentuximab vedotin (BV) in combination with cyclophosphamide, doxorubicin, and prednisone (BV-CHP) vs cyclophosphamide, doxorubicin, vincristine, and prednisone in the ECHELON-2 trial are practice changing for common nodal CD30+ PTCLs. Questions regarding the optimal cutoff of CD30 expression for BV-CHP therapy and the efficacy and safety of BV-CHP in less common subtypes of CD30+ PTCL subtypes await clarification.

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