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Comment
. 2019 Nov 6;104(3):429-430.
doi: 10.1016/j.neuron.2019.10.021.

Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity

Joanna Lipka  1 , Casper C Hoogenraad  2
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Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity

Joanna Lipka et al. Neuron. .
Free article

Abstract

Accumulation of abnormal Tau is a characteristic feature of a number of neurodegenerative disorders, called tauopathies. What is the reason for Tau toxicity in neuronal cells? In this issue of Neuron, Sohn et al. (2019) found that FTD mutant Tau-V337M blocks axon initial segment (AIS) plasticity, causing neuronal hyperexcitability.

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