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Comment
. 2019 Nov 7;134(19):1565-1566.
doi: 10.1182/blood.2019002983.

The long and the short of it

David M Bodine
Comment

The long and the short of it

David M Bodine. Blood. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
Full-length forms and short forms of the GATA1 protein. A map of the Gata1 locus is shown in the center (Gata1 gene). The exons are shown as blocks. Gray indicates noncoding sequence; blue indicates coding sequence. Above the gene, a spliced, full-length Gata1 messenger RNA (mRNA) is shown with the AUG initiation codon indicated. This RNA is translated into full-length GATA1 protein (top). The N-terminal domain, the N-terminal zinc finger (NF), and the C-terminal zinc finger (CF) are indicated. Below the gene, a spliced variant Gata1 mRNA encoding the variant GATA1s protein is shown, with the alternative GATA1s AUG initiation codon indicated. This RNA is translated as the GATA1s protein. The N-terminal zinc finger and the C-terminal zinc finger are indicated.
See this image and copyright information in PMC

Comment on

References

    1. Ling T, Birger Y, Stankiewicz MJ, et al. . Chromatin occupancy and epigenetic analysis reveal new insights into the function of GATA1 N terminus in erythropoiesis. Blood. 2019;134(19):1619-1631. - PMC - PubMed
    1. Katsumura KR, Bresnick EH; GATA Factor Mechanisms Group . The GATA factor revolution in hematology. Blood. 2017;129(15):2092-2102. - PMC - PubMed
    1. Pevny L, Simon MC, Robertson E, et al. . Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 1991;349(6306):257-260. - PubMed
    1. Shimizu R, Yamamoto M. Gene expression regulation and domain function of hematopoietic GATA factors. Semin Cell Dev Biol. 2005;16(1):129-136. - PubMed
    1. Crispino JD, Horwitz MS. GATA factor mutations in hematologic disease. Blood. 2017;129(15):2103-2110. - PMC - PubMed