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Comment
. 2019 Oct 31;134(18):1484-1485.
doi: 10.1182/blood.2019003022.

A fork in the road

Anupama Narla  1 , Narla Mohandas  2
Affiliations
Comment

A fork in the road

Anupama Narla et al. Blood. .

Abstract

In this issue of Blood, Xavier-Ferrucio et al provide new insights into the mechanisms responsible for the well-documented finding of thrombocytosis in patients with iron deficiency anemia. By using mouse and human models, they document that a low iron content in the bone marrow environment affects the megakaryocyte-erythroid progenitors (MEPs). This occurs because of induced alteration in their metabolism, attenuation of ERK signaling, slowing of cell proliferation, and biasing of the MEPs toward megakaryocyte commitment, which ultimately results in thrombocytosis and anemia.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
Model describing how iron may regulate the road taken by MEP when it arrives at the fork to choose between red cell vs platelet production.
See this image and copyright information in PMC

Comment on

References

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