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. 2019 Nov 7;19(1):165.
doi: 10.1186/s12893-019-0635-0.

A prospective single-center protocol for using near-infrared fluorescence imaging with indocyanine green during staging laparoscopy to detect small metastasis from pancreatic cancer

Sachiyo Shirakawa  1 , Hirochika Toyama  2 , Masahiro Kido  2 , Takumi Fukumoto  2
Affiliations

A prospective single-center protocol for using near-infrared fluorescence imaging with indocyanine green during staging laparoscopy to detect small metastasis from pancreatic cancer

Sachiyo Shirakawa et al. BMC Surg. .

Abstract

Background: Pancreatic resection and radiotherapy are powerful tools in the multidisciplinary local treatment of pancreatic ductal adenocarcinoma (PDAC). However, 10-20% of patients with preoperatively resectable PDAC have radiographically occult metastases, which results in laparotomy without resection. This study aims to explore the utility of intraoperative near-infrared (NIR) imaging with indocyanine green (ICG) during staging laparoscopy to detect PDAC metastasis.

Methods: This prospective study will evaluate patients with radiographically non-metastatic PDAC before they undergo planned pancreatic resection or chemoradiotherapy. Enrolled patients will receive ICG intravenously (0.5 mg/kg) before the staging laparoscopy. During the staging laparoscopy, the abdominal cavity will be observed using standard white-light laparoscopic imaging and then using NIR-ICG imaging. Suspicious lesions that are detected using standard imaging and/or NIR-ICG imaging will be examined intraoperatively using frozen sections and permanent specimens. We will evaluate the benefit of NIR-ICG imaging based on its ability to identify additional liver or peritoneal lesions that were not detected during standard white-light imaging.

Discussion: This study will help establish the clinical utility of NIR-ICG imaging to more precisely identify metastases from radiographically non-metastatic PDAC. This approach may help avoid needless major surgery or radiotherapy.

Trial registration: This protocol was registered on April 1, 2017 on the UMIN Clinical Trials Registry: UMIN000025900 and February 26, 2019 on the Japan Registry of Clinical Trials: jRCT1051180076.

Keywords: Indocyanine green; Liver metastasis; Pancreatic cancer; Peritoneal metastasis; Staging laparoscopy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Therapeutic decision making by staging laparoscopy. SL: staging laparoscopy; PWC: peritoneal washing cytology
Fig. 2
Fig. 2
Flowchart for this study. PDAC: pancreatic ductal adenocarcinoma; SL: staging laparoscopy; PWC: peritoneal washing cytology
See this image and copyright information in PMC

Comment in

References

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