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Comment
. 2019 Nov 8;366(6466):684-685.
doi: 10.1126/science.aaz4859.

Beyond the genome: RNA control of stem cells

Haibin Xi  1 , April Pyle  2
Affiliations
Comment

Beyond the genome: RNA control of stem cells

Haibin Xi et al. Science. .
No abstract available

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Figures

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Regulation of stem cell behavior by multiple RNA species
Diaphragm muscle stem cells express high amounts of paired box protein 3 (PAX3), causing increased rates of proliferation. This is mediated by low expression of U1 small nuclear RNA (snRNA), which promotes use of the proximal polyadenylation sites (P1 and P2) in the untranslated region (UTR) and thus short messenger RNAs (mRNAs) that are not targeted by microRNA-206 (miR206). In hindlimb muscle stem cells, high amounts of U1 snRNA favor the distal polyadenylation site (D1) and the generation of long mRNAs with miR206 binding sites.
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References

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