Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Jan;102(1):156-158.
doi: 10.4269/ajtmh.19-0643.

Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase Deficient Malaria Patient in Southeastern Bangladesh

Ching Swe Phru  1 , Mohammad Golam Kibria  1 , Kamala Thriemer  2 , Mahtab Uddin Chowdhury  3 , Nusrat Jahan  1 , M M Aktaruzzaman  4 , Hisni Rahmat  5 , Ari Winasti Satyagraha  5 , Aung Swi Prue  3 , Wasif Ali Khan  1 , Benedikt Ley  2 , Mohammad Shafiul Alam  1
Affiliations
Case Reports

Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase Deficient Malaria Patient in Southeastern Bangladesh

Ching Swe Phru et al. Am J Trop Med Hyg. 2020 Jan.

Abstract

We herein report the first case of Mediterranean glucose-6-phosphate dehydrogenase (G6PD) variant from Bangladesh. A boy had been admitted to hospital and was diagnosed with uncomplicated Plasmodium vivax infection and treated with 30 mg/kg body weight (BW) chloroquine for 3 days and 4.8 mg/kg BW primaquine (PQ) to be taken over 14 days. The boy was discharged but represented 4 days later with severe hemoglobinuria and fatigue. Hemoglobin was measured at 6.0 g/dL and serum bilirubin was at 5.6 mg/dL, although malaria microscopy was negative. The boy had taken the 4-fold recommended daily dose of PQ and was treated with two fresh blood transfusions. Subsequent molecular analysis showed the boy to have the Mediterranean G6PD variant and a G6PD activity of 0.93 U/gHb.

PubMed Disclaimer

References

    1. NMEP , 2019. Malaria MIS Report. National Malaria Elimination Program DCD, Directorate General of Health Services Ministry of Health & Family Welfare Government of Bangladesh. Dhaka, Bangladesh: NMEP.
    1. National Malaria Control Program DCD, Directorate General of Health Services Ministry of Health & Family Welfare Government of Bangladesh , 2016. The Diagnosis and Management of Malaria (Early Diagnosis and Prompt Treatment) EDPT Learners Guide 2016. Dhaka, Bangladesh, 5.
    1. Baird JK, Hoffman SL, 2004. Primaquine therapy for malaria. Clin Infect Dis 39: 1336–1345. - PubMed
    1. Chu CS, Bancone G, Nosten F, White NJ, Luzzatto L, 2018. Primaquine-induced haemolysis in females heterozygous for G6PD deficiency. Malar J 17: 101. - PMC - PubMed
    1. World Health Organization , 2015. Guidelines for the Treatment of Malaria, 3rd edition Available at: http://apps.who.int/medicinedocs/documents/s21839en/s21839en.pdf. Accessed March 3, 2019. - PubMed

Publication types