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Observational Study
. 2019 Nov;98(45):e17899.
doi: 10.1097/MD.0000000000017899.

Short-term exposure to particulate matters is associated with septic emboli in infective endocarditis

Fu-Chien Hsieh  1 , Chun-Yen Huang  2 , Sheng-Feng Lin  3 , Jen-Tang Sun  2 , Tzung-Hai Yen  4   5   6 , Chih-Chun Chang  3
Affiliations
Observational Study

Short-term exposure to particulate matters is associated with septic emboli in infective endocarditis

Fu-Chien Hsieh et al. Medicine (Baltimore). 2019 Nov.

Abstract

This survey was to investigate the short-term effect of particulate matters (PMs) exposure on clinical and microbiological variables, especially septic emboli, in infective endocarditis (IE). The study analyzed 138 IE patients in Far Eastern Memorial Hospital from 2005 to 2015 and clinical variables were retrospectively requested. The data of air quality were recorded and collected by a network of 26 monitoring stations spreading in Northern part of Taiwan. We found that IE patients with septic emboli were found to be exposed to a significantly higher level of PM2.5 (32.01 ± 15.89 vs. 21.70 ± 13.05 μg/m, P < .001) and PM10 (54.57 ± 24.43 vs 40.98 ± 24.81 μg/m, P = .002) on lag 0 day when compared to those without. Furthermore, multivariate regression analysis revealed that that ambient exposure to PM2.5 (odds ratio: 3.87, 95% confidence interval: 1.31-8.31; P = .001) and PM10 (odds ratio: 4.58, 95% confidence interval: 2.03-10.32; P < .001) significantly increased risk of septic emboli in IE patients. To our knowledge, this is the first study demonstrating that short-term exposure to PMs was associated with septic emboli in IE.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

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