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Comment
. 2019 Nov 7;25(5):589-591.
doi: 10.1016/j.stem.2019.10.008.

The Princess and the P: Pluripotent Stem Cells and P-Bodies

Juliane O Viegas  1 , Eran Meshorer  2
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Comment

The Princess and the P: Pluripotent Stem Cells and P-Bodies

Juliane O Viegas et al. Cell Stem Cell. .
Free article

Abstract

In this issue of Cell Stem Cell, Di Stefano et al. (2019) identify the RNA helicase DDX6 as a regulator of stem cell pluripotency and differentiation. DDX6 depletion leads to P-body disruption, which, in turn, inhibits or promotes stem and progenitor cell differentiation, depending on their cellular context.

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  • The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis.
    Di Stefano B, Luo EC, Haggerty C, Aigner S, Charlton J, Brumbaugh J, Ji F, Rabano Jiménez I, Clowers KJ, Huebner AJ, Clement K, Lipchina I, de Kort MAC, Anselmo A, Pulice J, Gerli MFM, Gu H, Gygi SP, Sadreyev RI, Meissner A, Yeo GW, Hochedlinger K. Di Stefano B, et al. Cell Stem Cell. 2019 Nov 7;25(5):622-638.e13. doi: 10.1016/j.stem.2019.08.018. Epub 2019 Oct 3. Cell Stem Cell. 2019. PMID: 31588046 Free PMC article.

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