Evolution of cerebral asymmetry

Abstract

The human brain is often characterized in terms of a duality, with the left and right brains serving complementary functions, and even individuals are sometimes classified as either "left-brained" or "right-brained." Recent evidence from brain imaging shows that hemispheric asymmetry is multidimensional, comprised of independent lateralized circuits. Cerebral asymmetries, which include handedness, probably arise in phylogenesis through the fissioning of ancestral systems that divided and lateralized with increasing demand for specialization. They also vary between individuals, with some showing absent or reversed asymmetries. It is unlikely that this variation is controlled by a single gene, as sometimes assumed, but depends rather on complex interplay among several, perhaps many, genes. Hemispheric asymmetry has often been regarded as a unique mark of being human, but it has also become evident that behavioral and cerebral asymmetries are not confined to humans, and are widespread among animal species. They nevertheless exist against a fundamental background of bilateral symmetry, suggesting a tradeoff between the two. Individual differences in asymmetry, moreover, are themselves adaptive, contributing to the cognitive and behavioral specializations necessary for societies to operate efficiently.

Keywords: Animal asymmetries; Bilateral symmetry; Cerebral asymmetry; Genes; Handedness; Hemispheric duality; Situs inversus.