Comment
doi: 10.1016/j.tins.2019.10.005.
Epub 2019 Nov 6.
Is There a Hemispheric Disconnect in Neurodevelopmental Disorders?
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- PMID: 31704178
- DOI: 10.1016/j.tins.2019.10.005
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Comment
Is There a Hemispheric Disconnect in Neurodevelopmental Disorders?
Trends Neurosci.
2019 Dec.
Abstract
The CYFIP1 gene has been linked to autism and schizophrenia and, while there is a noted heterogeneity, both have been characterized to be disorders of connectivity. Recent studies by Dominquez-Iturza et al. and Silva et al. provide direct evidence for CYFIP1 in functional and structural connectivity in the brain.
Keywords: Cyfip1; autism; diffusion tensor imaging; magnetic resonance imaging; mouse; schizophrenia.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Comment on
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The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour.Nat Commun. 2019 Aug 1;10(1):3454. doi: 10.1038/s41467-019-11203-y. Nat Commun. 2019. PMID: 31371726 Free PMC article.
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Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility.Nat Commun. 2019 Aug 1;10(1):3455. doi: 10.1038/s41467-019-11119-7. Nat Commun. 2019. PMID: 31371763 Free PMC article.
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