Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019:65:91-96.
doi: 10.1016/j.ijscr.2019.10.033. Epub 2019 Oct 24.

Gigantic submandibular pleomorphic adenoma: A rare case report

Mohamed Abdelkhalek  1 , Mohamed Elmetwally  2 , Alaa Mazy  3 , Mona Gad  3 , Ahmed Elsaid  4 , Shadi Awny  2 , Basel Refky  2 , Ahmed Abdallah  2 , Amr F Elalfy  2 , Farida A Shokeir  4 , Samar Abdallah  2 , Abeer Elfeky  2 , Rowaa Aboelamayem  4 , Mohamed A Hegazy  2
Affiliations

Gigantic submandibular pleomorphic adenoma: A rare case report

Mohamed Abdelkhalek et al. Int J Surg Case Rep. 2019.

Abstract

Introduction: Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. When neglected on some occasions, its size and weight can enormously augment.

Case presentation: We report a case of a giant submandibular pleomorphic adenoma in a 75 years old female patient which measured 34 × 26 × 20 cm and weighed 8.1 kg.

Conclusion: Neglecting such tumors without treatment, can cause severe facial disfigurement and can even hinder the airway.

Keywords: Giant; Pleomorphic adenoma; Submandibular gland.

PubMed Disclaimer

Conflict of interest statement

There is no conflict of interests.

Figures

Fig. 1
Fig. 1
Preoperative antero-posterior view.
Fig. 2
Fig. 2
Preoperative lateral view.
Fig. 3
Fig. 3
CT angiography (antero-posterior view).
Fig. 4
Fig. 4
CT angiography (lateral view).
Fig. 5
Fig. 5
Inferolateral incision.
Fig. 6
Fig. 6
Intraoperative dissection.
Fig. 7
Fig. 7
Postoperative specimen.
Fig. 8
Fig. 8
Covering with Thiersch graft.
Fig. 9
Fig. 9
Pleomorphic adenoma shows alternating.
Fig. 10
Fig. 10
Sheets of epithelial and myoepithelial cells. (H&E. ×40).
Fig. 11
Fig. 11
Acinar structures lined by epithelial cells admixed with myo-epithelial cells and myxoid matrix. (H&E. ×100).
Fig. 12
Fig. 12
Dystrophic calcification (Hx&E, ×400).
Fig. 13
Fig. 13
Infarction necrosis exhibiting ghosts of cells (Hx&E, ×40).
Fig. 14
Fig. 14
Nuclear positivity of ki67 in 2% of tumor cells (×40).
See this image and copyright information in PMC

References

    1. Pinkston J.A., Cole P. Incidence rates of salivary gland tumors: results from a population-based study. Otolaryngol. Head Neck. 1999;120:834. - PubMed
    1. Molina E.J., Mayer K., Khurana J., Grewal H. Pleomorphic adenoma of the submandibular gland. J. Pediatr. Surg. 2008;43:1224–1226. - PubMed
    1. Perumal C.J., Meyer M., Mohamed A. A giant pleomorphic adenoma of the submandibular salivary gland: a case report. Craniomaxillofac. Trauma Reconstr. 2012;5(3):185–188. - PMC - PubMed
    1. Thoeny H.C. Imaging of salivary gland tumours. Cancer Imaging. 2007;7:52–62. - PMC - PubMed
    1. Agha R.A., Borrelli M.R., Farwana R., Koshy K., Fowler A., Orgill D.P., For the SCARE group The SCARE 2018 statement: updating consensus surgical CAse REport (SCARE) guidelines. Int. J. Surg. 2018;60:132–136. - PubMed