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. 2019 Oct;5(10):577-579.
doi: 10.1016/j.trecan.2019.08.002. Epub 2019 Aug 31.

Phages Enter the Fight against Colorectal Cancer

Vinicius Kannen  1 , Lee Parry  2 , Francis L Martin  3
Affiliations
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Phages Enter the Fight against Colorectal Cancer

Vinicius Kannen et al. Trends Cancer. 2019 Oct.

Abstract

Intestinal microbiota undergo significant changes in colorectal cancer (CRC). Zheng et al. (Nat. Biomed. Eng., 2019) observe detrimental overpopulation of Fusobacterium nucleatum in mice and patients, suppressing the beneficial butyrate-producing Clostridium butyricum. Phage-guided irinotecan-loaded dextran nanoparticles promote release of bacterial-derived butyrate, while F. nucleatum and CRC cells are eliminated. These findings describe a possible novel therapeutic strategy for CRC.

Keywords: bacteriophage; chemotherapy; colorectal cancer; microbiota.

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