Long term outcomes in chronic lung disease requiring tracheostomy and chronic mechanical ventilation

Abstract

Bronchopulmonary dysplasia (BPD) is the most common serious complication associated with preterm birth. Infants with severe BPD often require prolonged and intensive pulmonary care. Among those with the most severe lung disease, this care may include tracheostomy and long-term invasive mechanical ventilation. Although there is a plethora of data on long term respiratory and developmental outcomes of BPD survivors, relevant information on BPD survivors requiring chronic respiratory failure are limited. When compared to those born at term gestation, infants with BPD requiring chronic ventilation are at increased risk of hospitalizations and develop more frequent lower respiratory infections. In childhood and young adulthood, spirometry often shows an obstructive flow pattern. From a neurodevelopmental standpoint, the short-term outcomes appear optimistic, with improvement in growth and increased participation in development-promoting activities. Nonetheless, children born prematurely are vulnerable for long term cognitive, educational and behavioral impairments. BPD is an additional risk factor which exacerbates these deficits, thus contributing to lifelong neurodevelopmental impairments of prematurity.

Keywords: Bronchopulmonary dysplasia; Chronic mechanical ventilation; Exercise testing; Neurodevelopmental outcomes; Pulmonary function; Respiratory outcomes; Systemic corticosteroids; Tracheostomy.