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. 2019 Nov;40(11):1171-1176.
doi: 10.15537/smj.2019.11.24584.

Overall survival of adult acute myeloid leukemia based on cytogenetic and molecular abnormalities during 5 years in a single center study

Enaam Alsobhi  1 , Fayssal Farahat, Mostafa Daghistani, Khadeja Awad, Omar Al-Zahran, Afaf Al-Saiari, Fai Koshak
Affiliations

Overall survival of adult acute myeloid leukemia based on cytogenetic and molecular abnormalities during 5 years in a single center study

Enaam Alsobhi et al. Saudi Med J. 2019 Nov.

Abstract

Objectives: To determined the 5-year overall survival (OS) rates for adult patients with acute myeloid leukemia (AML) patients at King Abdulaziz Medical City, Jeddah, Saudi Arabia, based on cytogenetic and molecular abnormalities. Methods: A retrospective cohort study reviewing adult AML patient files between 2011 and 2018. Sixty-three patients were excluded due to pediatric age and secondary AML. The remaining 87 adult patients with de novo AML were enrolled in this study.

Results: The most frequent cytogenetic abnormalities were t(15;17) (17.2%), followed by complex cytogenetic (13.8%) and t(8;21) (5.7%). The most frequent molecular abnormalities were promyelocytic leukemia/retinoic acid receptor alpha (PML-RARA) (16.1%) and Nucleophosmin 1 (NPM1) (11.5%). The highest OS rate was associated with t(15;17), PML-RARA, and NPM. However, complex cytogenetic was associated with the lowest OS rate; fms-like tyrosine kinase 3 (FLT3)-internal tandem duplication was independently correlated with low OS rate. Conclusion: The study describes cytogenetic and molecular abnormalities observed in adult AML patients and gives an overview of prognostic factors and determine the OS, with comparable results with recent published data by the WHO.

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Figures

Figure 1
Figure 1
Kaplan–Meier curve and Cox-regression analysis of genes associated with better prognosis.
Figure 2
Figure 2
Kaplan-Meier curve and Cox-regression analysis of factors with poor prognosis.
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References

    1. Dohner H, Weisdorf DJ, Bloomfield CD. Acute myeloid leukemia. N Engl J Med. 2015;373:1136–1152. - PubMed
    1. American Cancer Society. What is acute myeloid leukemia. Atlanta: American Cancer Society; 2018.
    1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide:IARC CancerBase No. 11 [Internet] Lyon (FR): International Agency for Research on Cancer; 2013.
    1. Saudi Cancer Registry. Cancer Incidence Report in Saudi Arabia 2014-2017. Riyadh (KSA): Saudi Cancer Registry; 2017.
    1. World Health Organization. AML classification biology and prognosis. Geneva: World Health Organization; 2017.