Effect of Aerobic Exercise on Peak Oxygen Consumption, VE/VCO₂ Slope, and Health-Related Quality of Life in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction: a Systematic Review and Meta-Analysis

Mansueto Gomes-Neto^{1

2

3

4}, André Rodrigues Durães⁵, Lino Sergio Rocha Conceição^{6

7}, Leonardo Roever⁸, Tong Liu^{9

10}, Gary Tse¹¹, Giuseppe Biondi-Zoccai¹², Ana Lucia Barbosa Goes^{13

14}, Iura Gonzalez Nogueira Alves¹⁴, Øyvind Ellingsen^{15

16}, Vitor Oliveira Carvalho^{6

7}

Affiliations

¹ Physical Therapy Department, Instituto de Ciências da Saúde, Federal University of Bahia - UFBA, Av. Reitor Miguel Calmon s/n - Vale do Canela Salvador, Salvador, Bahia, CEP 40.110-100, Brazil. mansueto.neto@ufba.br.
² Programa de Pós-Graduação em Medicina e Saúde, UFBA, Salvador, BA, Brazil. mansueto.neto@ufba.br.
³ Physiotherapy Research Group, UFBA, Salvador, Brazil. mansueto.neto@ufba.br.
⁴ The GREAT Group (GRupo de Estudos em ATividade física), São Paulo, Brazil. mansueto.neto@ufba.br.
⁵ Programa de Pós-Graduação em Medicina e Saúde, UFBA, Salvador, BA, Brazil.
⁶ The GREAT Group (GRupo de Estudos em ATividade física), São Paulo, Brazil.
⁷ Physical Therapy Department, Federal University of Sergipe - UFS, Aracaju, SE, Brazil.
⁸ Department of Clinical Research, Federal University of Uberlândia, Uberlândia, Brazil.
⁹ Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
¹⁰ Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
¹¹ Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
¹² Mediterranea Cardiocentro, Naples, Italy.
¹³ Physical Therapy Department, Instituto de Ciências da Saúde, Federal University of Bahia - UFBA, Av. Reitor Miguel Calmon s/n - Vale do Canela Salvador, Salvador, Bahia, CEP 40.110-100, Brazil.
¹⁴ Physiotherapy Research Group, UFBA, Salvador, Brazil.
¹⁵ K.G. Jebsen Center for Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
¹⁶ Department of Cardiology, Trondheim University Hospital, St. Olavs Hospital, Trondheim, Norway.

PMID: 31707525
DOI: 10.1007/s11883-019-0806-6

Meta-Analysis

Effect of Aerobic Exercise on Peak Oxygen Consumption, VE/VCO₂ Slope, and Health-Related Quality of Life in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction: a Systematic Review and Meta-Analysis

Mansueto Gomes-Neto et al. Curr Atheroscler Rep. 2019.

. 2019 Nov 9;21(11):45.

doi: 10.1007/s11883-019-0806-6.

Authors

Affiliations

¹ Physical Therapy Department, Instituto de Ciências da Saúde, Federal University of Bahia - UFBA, Av. Reitor Miguel Calmon s/n - Vale do Canela Salvador, Salvador, Bahia, CEP 40.110-100, Brazil. mansueto.neto@ufba.br.
² Programa de Pós-Graduação em Medicina e Saúde, UFBA, Salvador, BA, Brazil. mansueto.neto@ufba.br.
³ Physiotherapy Research Group, UFBA, Salvador, Brazil. mansueto.neto@ufba.br.
⁴ The GREAT Group (GRupo de Estudos em ATividade física), São Paulo, Brazil. mansueto.neto@ufba.br.
⁵ Programa de Pós-Graduação em Medicina e Saúde, UFBA, Salvador, BA, Brazil.
⁶ The GREAT Group (GRupo de Estudos em ATividade física), São Paulo, Brazil.
⁷ Physical Therapy Department, Federal University of Sergipe - UFS, Aracaju, SE, Brazil.
⁸ Department of Clinical Research, Federal University of Uberlândia, Uberlândia, Brazil.
⁹ Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
¹⁰ Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
¹¹ Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
¹² Mediterranea Cardiocentro, Naples, Italy.
¹³ Physical Therapy Department, Instituto de Ciências da Saúde, Federal University of Bahia - UFBA, Av. Reitor Miguel Calmon s/n - Vale do Canela Salvador, Salvador, Bahia, CEP 40.110-100, Brazil.
¹⁴ Physiotherapy Research Group, UFBA, Salvador, Brazil.
¹⁵ K.G. Jebsen Center for Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
¹⁶ Department of Cardiology, Trondheim University Hospital, St. Olavs Hospital, Trondheim, Norway.

PMID: 31707525
DOI: 10.1007/s11883-019-0806-6

Abstract

Purpose of review: The aim of this study was to determine the effects of aerobic exercise on peak oxygen uptake (peak VO₂), minute ventilation/carbon dioxide production (VE/VCO₂ slope), and health-related quality of life (HRQoL) among patients with heart failure (HF) and preserved ejection fraction (HFpEF).

Recent findings: We conducted a Cochrane Library, MEDLINE/PubMed, Physiotherapy Evidence Database, and SciELO search (from 1985 to May 2019) for randomized controlled trials that evaluated the effects of aerobic exercise in HFpEF patients. We calculated the mean differences (MD) and 95% confidence interval (CI). Ten intervention studies were included providing a total of 399 patients. Compared with control, aerobic exercise resulted in improvement in peak VO₂ MD 1.9 mL kg^-1 min^-1 (95% CI 1.3 to 2.5; N = 314) and HRQoL measured by Minnesota Living with Heart Failure MD 5.4 (95% CI - 10.5 to - 0.2; N = 256). No significant difference in VE/VCO₂ slope was found between participants in the aerobic exercise group and the control group. The quality of evidence for peak VO₂ and HRQoL was assessed as being moderate. Aerobic exercise moderately improves peak VO₂ and HRQoL and should be considered a strategy of rehabilitation of HFpEF individuals.

Keywords: Aerobic exercise; Heart failure; Left ventricular ejection fraction.

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References

1. JAMA. 2016 Jan 5;315(1):36-46 - PubMed
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Effect of Aerobic Exercise on Peak Oxygen Consumption, VE/VCO₂ Slope, and Health-Related Quality of Life in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction: a Systematic Review and Meta-Analysis

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Effect of Aerobic Exercise on Peak Oxygen Consumption, VE/VCO₂ Slope, and Health-Related Quality of Life in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction: a Systematic Review and Meta-Analysis

Authors

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Abstract

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