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Meta-Analysis
. 2019 Nov 10;7(1):176.
doi: 10.1186/s40478-019-0834-z.

Pediatric methylation class HGNET-MN1: unresolved issues with terminology and grading

Arnault Tauziède-Espariat  1   2 , Mélanie Pagès  3   4 , Alexandre Roux  4   5 , Aurore Siegfried  6 , Emmanuelle Uro-Coste  6 , Yvan Nicaise  6 , Annick Sevely  7 , Marion Gambart  8 , Sergio Boetto  9 , Martin Dupuy  10 , Pomone Richard  11 , Romain Perbet  12 , Matthieu Vinchon  13 , Sabine Caron  14 , Felipe Andreiuolo  3   4 , Albane Gareton  3   4 , Emmanuèle Lechapt  3   4 , Fabrice Chrétien  3   4 , Stéphanie Puget  4   15 , Jacques Grill  4   16   17 , Nathalie Boddaert  4   18 , Pascale Varlet  3   4 ; RENOCLIP-LOC
Affiliations
Meta-Analysis

Pediatric methylation class HGNET-MN1: unresolved issues with terminology and grading

Arnault Tauziède-Espariat et al. Acta Neuropathol Commun. .
No abstract available

Keywords: Astroblastoma; HGNET; MN1; Meta-analysis.

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Conflict of interest statement

The authors declare that they have no conflicts of interest directly related to the topic of this article.

Figures

Fig. 1
Fig. 1
Results of the meta-analysis and prognostic data of HGNET-MN1. (a) Integrative annotation of histopathologic features (mitotic index, microvascular proliferation -MVP- and necrosis), treatment (surgery and adjuvant therapy -adj. Therapy-) and follow-up of our cases and cases of the literature included in the meta-analysis (b) There is no significant difference in terms of PFS and OS between HGNET-MN1 with or without elevated mitotic index (p = 0.094 and 0.461 respectively), microvascular proliferation (p = 0.379 and 0.423, respectively) and necrosis (p = 0.301 and 0.426, respectively).(c) Results of the meta-analysis including 32 ependymomas, RELA-fusion (EPN-RELA, n = 32), HGENT-MN1 (n = 24), 19 ependymomas, YAP1-fusion (EPN-YAP1, n = 19), and HGNET-BCOR (n = 28). Kaplan–Meier estimates of overall survival (OS) and progression free survival (PFS) according to DNA-methylation subgroups: There is a significant difference in terms of PFS (p < 0.001) and OS (p < 0.001) between EPN-RELA, EPN-YAP1, HGNET-BCOR and HGNET-MN1
See this image and copyright information in PMC

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