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Case Reports
. 2019 Nov-Dec;10(6):1050-1053.
doi: 10.1016/j.jcot.2019.09.006. Epub 2019 Sep 10.

Multicentric Giant Cell Tumor (GCT) of bone treated with denosumab alone: A report of two cases

Rishi Ram Poudel  1 , Vivek Verma  1 , Akshay Tiwari  1
Affiliations
Case Reports

Multicentric Giant Cell Tumor (GCT) of bone treated with denosumab alone: A report of two cases

Rishi Ram Poudel et al. J Clin Orthop Trauma. 2019 Nov-Dec.
No abstract available

Keywords: Denosumab; Metachronous GCT; Multicentric GCT; Synchronous GCT.

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Figures

Fig. 1
Fig. 1
22 -year female with eccentric epi-metaphyseal lytic lesion proximal tibia (Right) with a narrow zone of transition AP and Lateral views.
Fig. 2
Fig. 2
Incidentally detected tibial diaphyseal lytic lesion (arrow).
Fig. 3
Fig. 3
Well-healed scapular and lumbar spine lesions, 5-years on Denosumab treatment.
Fig. 4
Fig. 4
Multicentric disease with involvement of distal femur, proximal tibia, distal tibia and talus.
Fig. 5
Fig. 5
Well healed (ossified) distal tibial and talar lesion after 35 months on Denosumab treatment.
See this image and copyright information in PMC

References

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    1. Vaishya R., Agarwal A.K., Vijay V., Vaish A. Metachronous multicentric giant cell tumour in a young woman. Case Rep. 2015 May 15;2015 (may15 1):bcr2015209368–bcr2015209368. - PMC - PubMed
    1. Stratil P.G., Stacy G.S. Multifocal metachronous giant cell tumor in a 15-year-old boy. Pediatr Radiol. 2005 Apr;35(4):444–448. - PubMed
    1. Palmerini E., Chawla N.S., Ferrari S. Denosumab in advanced/unresectable giant-cell tumour of bone (GCTB): for how long? Eur J Cancer. 2017 May;76:118–124. - PubMed
    1. Luo Y., Tang F., Wang Y. Safety and efficacy of denosumab in the treatment of pulmonary metastatic giant cell tumor of bone. Cancer Manag Res. 2018 Jul;10:1901–1906. - PMC - PubMed

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