Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2019 Jun 29;4(3):158-164.
doi: 10.1136/svn-2019-000242. eCollection 2019 Sep.

The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics

Yongjun Wang  1   2   3   4 , Jing Jing  1   2   3   4 , Xia Meng  1   2   3   4 , Yuesong Pan  1   2   3   4 , Yilong Wang  1   2   3   4 , Xingquan Zhao  1   2   3   4 , Jinxi Lin  1   2   3   4 , Wei Li  1   2   3   4 , Yong Jiang  1   2   3   4 , Zixiao Li  1   2   3   4 , Xinmiao Zhang  1   2   3   4 , Xiaomeng Yang  1   2   3   4 , Ruijun Ji  1   2   3   4 , Chunjuan Wang  1   2   3   4 , Zhimin Wang  5 , Xinsheng Han  6 , Songdi Wu  7 , Zhengchang Jia  8 , Yongming Chen  9 , Hao Li  1   2   3   4
Affiliations
Multicenter Study

The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics

Yongjun Wang et al. Stroke Vasc Neurol. .

Abstract

Background and purpose: Stroke is the leading cause of mortality and disability in China. Precise aetiological classification, imaging and biological markers may predict the prognosis of stroke. The Third China National Stroke Registry (CNSR-III), a nationwide registry of ischaemic stroke or transient ischaemic attack (TIA) in China based on aetiology, imaging and biology markers, will be considered to clarify the pathogenesis and prognostic factors of ischaemic stroke.

Methods: Between August 2015 and March 2018, the CNSR-III recruited consecutive patients with ischaemic stroke or TIA from 201 hospitals that cover 22 provinces and four municipalities in China. Clinical data were collected prospectively using an electronic data capture system by face-to-face interviews. Patients were followed for clinical outcomes at 3 months, 6 months and 1-5 year annually. Brain imaging, including brain MRI and CT, were completed at baseline. Blood samples were collected and biomarkers were tested at baseline.

Results: A total of 15 166 stroke patients were enrolled, among which 31.7% patients were women with the average age of 62.2±11.3 years. Ischaemic stroke was predominant (93.3%, n=14 146) and 1020 (6.7%) TIAs were enrolled.

Conclusions: CNSR-III is a large scale nationwide registry in China. Data from this prospective registry may provide opportunity to evaluate imaging and biomarker prognostic determinants of stroke.

Keywords: biomarker; outcome; registry; stroke; transient ischaemic attack.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
The geographical locations of participating hospitals in the Third China National Stroke Registry.
Figure 2
Figure 2
Flow chart of patient enrolment in the Third China National Stroke Registry. TIA, transient ischaemic attack.
See this image and copyright information in PMC

References

    1. Zhou M, Wang H, Zhu J, et al. . Cause-specific mortality for 240 causes in China during 1990-2013: a systematic subnational analysis for the Global Burden of Disease Study 2013. Lancet 2016;387:251–72. 10.1016/S0140-6736(15)00551-6 - DOI - PubMed
    1. GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018;392:1736–88. 10.1016/S0140-6736(18)32203-7 - DOI - PMC - PubMed
    1. Wang Y, Cui L, Ji X, et al. . The China National Stroke Registry for patients with acute cerebrovascular events: design, rationale, and baseline patient characteristics. Int J Stroke 2011;6:355–61. 10.1111/j.1747-4949.2011.00584.x - DOI - PubMed
    1. Kernan WN, Ovbiagele B, Black HR, et al. . Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014;45:2160–236. 10.1161/STR.0000000000000024 - DOI - PubMed
    1. Li L, Yiin GS, Geraghty OC, et al. . Incidence, outcome, risk factors, and long-term prognosis of cryptogenic transient ischaemic attack and ischaemic stroke: a population-based study. Lancet Neurol 2015;14:903–13. 10.1016/S1474-4422(15)00132-5 - DOI - PMC - PubMed

Publication types

MeSH terms