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. 2019 Dec;21(6):1218-1224.
doi: 10.1111/cid.12866. Epub 2019 Nov 11.

Relationship between self-rated pain and peri-implant clinical, radiographic and whole salivary inflammatory markers among patients with and without peri-implantitis

Tariq Abduljabbar  1 , Fahim Vohra  1 , Anhar Ullah  2 , Nawaf Alhamoudi  3 , Junad Khan  4 , Fawad Javed  5
Affiliations

Relationship between self-rated pain and peri-implant clinical, radiographic and whole salivary inflammatory markers among patients with and without peri-implantitis

Tariq Abduljabbar et al. Clin Implant Dent Relat Res. 2019 Dec.

Abstract

Background: There are no studies that have evaluated the correlation between self-rated pain, peri-implant clinical and radiographic parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD], and crestal bone loss [CBL]) and whole salivary interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α) levels among patients with and without peri-implantitis.

Purpose: The objective was to evaluate the correlation between self-evaluated pain, peri-implant clinical and radiographic parameters and whole salivary IL-1β, IL-6, and TNF-α levels among patients with and without peri-implantitis.

Materials and methods: Included in this study were patients with and without peri-implantitis. Data regarding age, gender, duration of implants in function, and self-perceived pain were recorded using a question. Self-rated pain was assessed using the numeric pain rating scale. Peri-implant PD, PI, BOP, and CBL were recorded and samples of unstimulated whole saliva samples were obtained. Whole salivary IL-1β, IL-6, and TNF-α were measured. Sample-size was approximated and group comparisons were completed. P-values <.05 were regarded as statistically significant.

Results: Forty-six male individuals (21 with and 25 without peri-implantitis) were included. The mean age of individuals with and without PiD was 53.71 ± 5.45 and 50.92 ± 6.26 years, respectively. The mean self-rated pain score in patients with and without PiD was 3 ± 2 and zero, respectively. There was no significant difference in the SFR among patients with and without peri-implantitis. Levels of IL-1β (P < .01), IL-6 (P < .01), and TNF-α (P < .01) were significantly elevated in subjects with than without peri-implantitis. Regression analysis-based results reflected no significant association between increasing self-rated pain and whole salivary IL-1β, IL-6, and TNF-α levels.

Conclusion: Proinflammatory cytokines (IL-1β, IL-6, and TNF-α) are more often expressed in the UWS of patients with than without peri-implantitis. However, the correlation between self-rated pain and whole salivary proinflammatory cytokine profile in patients with peri-implantitis remains unclear.

Keywords: cytokine; inflammation; pain; peri-implantitis; unstimulated whole saliva.

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