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Meta-Analysis
. 2019 Dec 20;39(12):BSR20192452.
doi: 10.1042/BSR20192452.

Comprehensive assessment of the association between XPC rs2228000 and cancer susceptibility based on 26835 cancer cases and 37069 controls

Yingqi Dai  1 , Zhonghua Song  1 , Jinqing Zhang  2 , Wei Gao  3   4   5
Affiliations
Meta-Analysis

Comprehensive assessment of the association between XPC rs2228000 and cancer susceptibility based on 26835 cancer cases and 37069 controls

Yingqi Dai et al. Biosci Rep. .

Abstract

Objectives In the present study, we examined available articles from online databases to comprehensively investigate the effect of the XPC (xeroderma pigmentosum complementation group C) rs2228000 polymorphism on the risk of different types of clinical cancer. Methods We conducted a group of overall and subgroup pooling analyses after retrieving the data from four databases (updated till September 2019). The P-value of association, OR (odds ratios), and 95% CI (confidence interval) were calculated. Results We selected a total of 71 eligible studies with 26835 cancer cases and 37069 controls from the 1186 retrieved articles. There is an enhanced susceptibility for bladder cancer cases under T vs. C [P=0.004; OR (95% CI) = 1.25 (1.07, 1.45)], TT vs. CC [P=0.001; 1.68 (1.25, 2.26)], CT+TT vs. CC [P=0.016; 1.26 (1.04, 1.53)], and TT vs. CC+ CT [P=0.001; 1.49 (1.18, 1.90)] compared with negative controls. Additionally, there is an increased risk of breast cancer under T vs. C, TT vs. CC and TT vs. CC+ CT (P<0.05, OR > 1). Nevertheless, there is a decreased risk of gastric cancer cases in China under T vs. C [P=0.020; 0.92 (0.85, 0.99)], CT vs. CC [P=0.001, 0.83 (0.73, 0.93)], and CT+TT vs. CC [P=0.003, 0.84 (0.76, 0.94)]. Conclusions The TT genotype of XPC rs2228000 may be linked to an increased risk of bladder and breast cancer, whereas the CT genotype is likely to be associated with reduced susceptibility to gastric cancer in the Chinese population.

Keywords: XPC; cancer; rs2228000; susceptibility.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. Selection process of eligible case–control studies
Figure 2
Figure 2. Subgroup analysis data by the factor of race under the T vs. C model
Figure 3
Figure 3. Subgroup analysis data by the factor of cancer type under the T vs. C model
Figure 4
Figure 4. Egger’s test plot and the sensitivity analysis data under the T vs. C model
(A) Egger’s test; (B) sensitivity analysis data.
Figure 5
Figure 5. TSA for the association between XPC rs2228000 and the risk of breast cancer under the TT vs. CC+CT model
See this image and copyright information in PMC

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