Role of vitamin K2 in bone metabolism: a point of view and a short reappraisal of the literature

Abstract

Vitamin K₂ (vit K₂) belongs to a large group of fat-soluble compounds whose formulation is MK (menaquinone) (MK-2 to MK-14), that seem to be involved in different biological functions. In particular, vit K₂ has been recently recognized as efficacious and safe in treatment of bone loss, as it contributes to structural integrity of osteocalcin (OC), the major non-collagenous protein typically found in bone matrix. Several studies proved low vit K₂ intake is linked to bone loss and to increased fracture risk in both sexes. Nowadays, vit K₂ supplementation is considered a significant manner to enhance the association of calcium and vitamin D whose role on bone health is largely recognized. On the other hand, vit K₂ may be used alone or with other drugs to preserve bone quality/strength from skeletal degradation after menopause and/or in patients affected by secondary osteoporosis. In this paper, we review the most recent data about vit K₂ on skeleton.

Keywords: Vitamin K2; bone; fracture; menaquinone; osteoporosis.