B cells in autoimmune and neurodegenerative central nervous system diseases

Joseph J Sabatino Jr^#^{1

2}, Anne-Katrin Pröbstel^#^{1

2

3}, Scott S Zamvil^{4

5

6}

Affiliations

¹ Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
² Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
³ Neurologic Clinic and Policlinic, Departments of Medicine and Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
⁴ Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. zamvil@ucsf.neuroimmunol.org.
⁵ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. zamvil@ucsf.neuroimmunol.org.
⁶ Program in Immunology, University of California, San Francisco, San Francisco, CA, USA. zamvil@ucsf.neuroimmunol.org.

^# Contributed equally.

PMID: 31712781
DOI: 10.1038/s41583-019-0233-2

Review

B cells in autoimmune and neurodegenerative central nervous system diseases

Joseph J Sabatino Jr et al. Nat Rev Neurosci. 2019 Dec.

. 2019 Dec;20(12):728-745.

doi: 10.1038/s41583-019-0233-2. Epub 2019 Nov 11.

Authors

Joseph J Sabatino Jr^#^{1

2}, Anne-Katrin Pröbstel^#^{1

2

3}, Scott S Zamvil^{4

5

6}

Affiliations

¹ Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
² Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
³ Neurologic Clinic and Policlinic, Departments of Medicine and Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
⁴ Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. zamvil@ucsf.neuroimmunol.org.
⁵ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. zamvil@ucsf.neuroimmunol.org.
⁶ Program in Immunology, University of California, San Francisco, San Francisco, CA, USA. zamvil@ucsf.neuroimmunol.org.

^# Contributed equally.

PMID: 31712781
DOI: 10.1038/s41583-019-0233-2

Erratum in

Publisher Correction: B cells in autoimmune and neurodegenerative central nervous system diseases.
Sabatino JJ Jr, Pröbstel AK, Zamvil SS. Sabatino JJ Jr, et al. Nat Rev Neurosci. 2020 Jan;21(1):56. doi: 10.1038/s41583-019-0251-0. Nat Rev Neurosci. 2020. PMID: 31772285

Abstract

B cells are essential components of the adaptive immune system and have important roles in the pathogenesis of several central nervous system (CNS) diseases. Besides producing antibodies, B cells perform other functions, including antigen presentation to T cells, production of proinflammatory cytokines and secretion of anti-inflammatory cytokines that limit immune responses. B cells can contribute to CNS disease either through their actions in the periphery (meaning that they have an 'outside-in' effect on CNS immunopathology) or following their compartmentalization within the CNS. The success of B cell-depleting therapy in patients with multiple sclerosis and CNS diseases with an autoantibody component, such as neuromyelitis optica spectrum disorder and autoimmune encephalitides, has underscored the role of B cells in both cellular and humoral-mediated CNS conditions. Emerging evidence suggests B cells also contribute to the pathogenesis of neurodegenerative diseases, including Alzheimer disease and Parkinson disease. Advancing our understanding of the role of B cells in neuroinflammatory and neurodegenerative diseases could lead to novel therapeutic approaches.

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References

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B cells in autoimmune and neurodegenerative central nervous system diseases

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B cells in autoimmune and neurodegenerative central nervous system diseases

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